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Dithiocarbamates (<jats:styled-content style=\"fixed-case\">DTC<\/jats:styled-content>) are organosulphur compounds widely used in agriculture, industry and households. We report a case of <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> after exposure to mancozeb in fungicide. A 48\u2010year\u2010old 75\u00a0kg b.w. man was admitted with fever and generalized skin\/mucous lesions after application of fungicide in a home garden. The patient had necrotic desquamation of gastrointestinal\/respiratory tract mucosa, ocular lesion and skin epidermolysis of 90% of body surface. The laboratory findings included elevation of inflammatory parameters, hyperglycaemia, increased urea, creatinine, liver enzymes, hypoalbuminemia and electrolyte disturbances. The treatment included supportive care, management of fluid\/electrolyte requirements, analgesics and enteral nutrition. Skin lesions were treated with occlusive non\u2010adhesive biological wound dressings. Due to the proof of <jats:italic>Acinetobacter<\/jats:italic>,<jats:italic> Escherichia coli<\/jats:italic> and <jats:italic>Escherichia faecalis<\/jats:italic> from skin swabs, a combination of meropenem with amikacin was administered. During the next 2\u00a0weeks, complete re\u2010epithelialization of skin lesions occurred, mucosal lesions healed and the laboratory parameters returned to normal. The patient was discharged on day 42. TEN is a rare condition that is generally caused by medications. Nevertheless, high attention should be paid to the cases of occupational or household exposure to DTC fungicides widely used in agriculture and home gardens because of their ability to cause <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> after skin and inhalation exposure. Greater emphasis on the hazardous properties of these products is necessary to ensure non\u2010professional users are aware of the necessity of protective clothing during mixing, loading, application and early re\u2010entry into treated fields.<\/jats:p>","DOI":"10.1111\/bcpt.12430","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T12:19:57Z","timestamp":1434197997000},"page":"87-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Toxic Epidermal Necrolysis After Exposure to Dithiocarbamate Fungicide Mancozeb"],"prefix":"10.1111","volume":"118","author":[{"given":"Sergey","family":"Zakharov","sequence":"first","affiliation":[{"name":"Toxicological Information Centre Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Csomor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine First Faculty of Medicine Charles University and Central Military Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Urbanek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine First Faculty of Medicine Charles University and Central Military Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pelclova","sequence":"additional","affiliation":[{"name":"Toxicological Information Centre Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.11.66"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.9"},{"key":"e_1_2_7_4_1","first-page":"413","article-title":"Clinical considerations for epidermal necrolysis","volume":"14","author":"Ellender RP","year":"2014","journal-title":"Oschner J"},{"key":"e_1_2_7_5_1","first-page":"287","volume-title":"Dermatology","author":"French LE","year":"2008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61112-X"},{"key":"e_1_2_7_7_1","first-page":"e121","article-title":"A systematic review of the treatment of drug\u2010induced Stevens\u2010Johnson syndrome and toxic epidermal necrolysis in children","volume":"18","author":"Pozzo\u2010Magana BR","year":"2011","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19064"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1983.tb04914.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-39"},{"key":"e_1_2_7_11_1","first-page":"77","article-title":"Drug\u2010hypersensitivity syndrome: diagnosis and treatment","volume":"3","author":"Hamm RL","year":"2012","journal-title":"J Am Col Certif Wound Spec"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.95103568"},{"key":"e_1_2_7_13_1","volume-title":"British Crop Protection Council and Tomlin, Clive The pesticide manual : a world compendium","author":"Tomlin","year":"2003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1976.tb03054.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1979.tb05530.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1980.tb04963.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1982.tb04217.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1985.tb02520.x"},{"key":"e_1_2_7_19_1","first-page":"7434","article-title":"Ethylene bisdithiocarbamates (EBDCs); 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