{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:47:56Z","timestamp":1765079276063},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the incidence of fatal adverse drug reactions (<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s) in a tertiary hospital to find out which drugs were involved. The secondary objective was to compare the data from the same hospital published 12\u00a0years earlier. All 1708 death cases in the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elsinki <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entral <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital during the year 2012 were retrospectively evaluated. All suspected drug\u2010related deaths, excluding suicides, were scrutinized by an expert panel using the <jats:styled-content style=\"fixed-case\">WHO ADR<\/jats:styled-content> probability classification. Of all cases, 52 (3.0%) were classified as certainly or probably drug related and 24 (1.4%) as possibly drug related. Together, these corresponded to 0.02% of all hospital admissions. The most commonly involved drugs in certain or probable cases were cytostatics (18 cases, 1.1% of all cases) and antithrombotics (17, 1.0%). Twelve years earlier, these caused 27 (1.8%) and 22 (1.5%) cases, respectively. Non\u2010steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) and glucocorticoids caused less (2 and 0 cases) fatal <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s than earlier (12 and 4 cases, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005, respectively). Most of the <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s leading to death were present already in admission and affected seriously ill or elderly patients. Hospital\u2010born fatal <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s occurred in 0.003% of patients. In conclusion, cytostatics and antithrombotics are still the leading causes of fatal <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s, but <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s and glucocorticoids seem to cause fatal <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s less often than previously. The incidence of fatal <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s in 2012 was 3.0% of all deaths, suggesting a decline compared to the 2000 value (5.0%). Improved awareness, prevention and treatment of <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s and safer medicines may explain these declining trends.<\/jats:p>","DOI":"10.1111\/bcpt.12435","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T09:55:58Z","timestamp":1435312558000},"page":"421-426","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Drug\u2010Related Inadvertent Deaths in a University Hospital \u2013 A Declining Trend"],"prefix":"10.1111","volume":"117","author":[{"given":"Outi","family":"Lapatto\u2010Reiniluoto","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Patinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Niemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janne T.","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pertti J.","family":"Neuvonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2012.00858.x"},{"key":"e_1_2_6_3_1","unstructured":"WHO.International drug monitoring: the role of national centres. 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