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The MiniReview presents the data of four available trials <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01193101, <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>00549770, <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>00887588 and <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01035255 and provides the current knowledge about <jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content>696 effects in patients with hypertension and heart failure. Presently, patients suffering from hypertension and heart failure are treated with <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibitors or angiotensin receptor antagonists often in combination with other drugs. These current medications lead to a reduction in blood pressure in hypertensive patients and a decreased mortality and morbidity in patients with heart failure with reduced ejection fraction, but not in patients with heart failure with preserved ejection fraction. <jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content>696 had been tested to utilize the beneficial properties of natriuretic peptides in combination with angiotensin receptor antagonism. It induces even greater blood pressure reductions and decreased mortality and morbidity in patients with heart failure with reduced ejection fraction, while patients with heart failure with preserved ejection fraction show lowered blood pressure and decreased <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro\u2010<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> levels. Although long\u2010term studies remain to be performed, these initial data suggest that there is a potential clinical benefit of <jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content>696 in the treatment of hypertension and heart failure.<\/jats:p>","DOI":"10.1111\/bcpt.12453","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T15:33:12Z","timestamp":1439825592000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["<scp>LCZ<\/scp>696 (Valsartan\/Sacubitril) \u2013 A Possible New Treatment for Hypertension and Heart Failure"],"prefix":"10.1111","volume":"118","author":[{"given":"Mathilde Borring","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Pharmacology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pharmacology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wehland","sequence":"additional","affiliation":[{"name":"Clinic for Plastic, Aesthetic and Hand Surgery Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Pietsch","sequence":"additional","affiliation":[{"name":"Clinic for Plastic, Aesthetic and Hand Surgery Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pharmacology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Global Atlas on Cardiovascular Disease Prevention and Control","author":"Mendis S","year":"2011"},{"key":"e_1_2_14_3_1","first-page":"1998","article-title":"[Hypertension\u2013prevalence and treatment]","volume":"171","author":"Ibsen H","year":"2009","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(55)90019-9"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2011.11.007"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00287.2006"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060342"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000388487.43460.db"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283437fcd"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.08.032"},{"key":"e_1_2_14_12_1","first-page":"e131","article-title":"Angiotensin receptor\u2010neprilysin inhibition with LCZ696: a novel approach for the treatment of heart failure","volume":"9","author":"Langenickel TH","year":"2012","journal-title":"Drug Discov Today"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.09.023"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01222.x"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-012-6392-2"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199207000-00002"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1201"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2003.09.014"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.797962"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.146"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009343932"},{"key":"e_1_2_14_22_1","unstructured":"https:\/\/clinicaltrials.gov. 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