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To do this, we included 10 healthy men who were examined by a 2\u2010hr oral glucose tolerance test on three occasions: A: baseline; B: after 21 days of treatment with St. John's wort; and C: at least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C\u2010peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration\u2013time curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) as well as indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> and 2\u2010hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long\u2010term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over\u2010the\u2010counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes.<\/jats:p>","DOI":"10.1111\/bcpt.12486","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T08:23:22Z","timestamp":1441700602000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impaired Glucose Tolerance in Healthy Men Treated with St. John's Wort"],"prefix":"10.1111","volume":"118","author":[{"given":"Tore Bjerregaard","family":"Stage","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Department of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Damkier","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department of Public Health University of Southern Denmark Odense Denmark"},{"name":"Department of 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