{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:49:35Z","timestamp":1787827775903,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Testicular torsion\/detorsion (T<\/jats:styled-content>\/D<\/jats:styled-content>) can induce depression in pre\u2010 and post\u2010pubertal patients. This study was conducted to investigate the psychological impact of testicular torsion and mechanism underlying its depressive\u2010like behaviour, as well as antidepressant\u2010like activity of minocycline and possible involvement of nitric oxide (NO<\/jats:styled-content>)\/cyclic GMP<\/jats:styled-content> pathway in this paradigm in male rats undergoing testicular T<\/jats:styled-content>\/D<\/jats:styled-content>. Unilateral T<\/jats:styled-content>\/D<\/jats:styled-content> was performed in 36 male adult W<\/jats:styled-content>istar rats, and different doses of minocycline were injected alone or combined with N<\/jats:italic>\u03c9<\/jats:sup>\u2010nitro\u2010l<\/jats:sc>\u2010arginine methyl ester (l<\/jats:sc>\u2010NAME<\/jats:styled-content>), non\u2010specific NO<\/jats:styled-content> synthase (NOS<\/jats:styled-content>) inhibitor; aminoguanidine (AG<\/jats:styled-content>), specific inducible NOS<\/jats:styled-content> inhibitor; l<\/jats:sc>\u2010arginine, an NO<\/jats:styled-content> precursor; and selective PDE<\/jats:styled-content>5I<\/jats:styled-content>, sildenafil. After assessment of locomotor activity in open\u2010field test, immobility times were recorded in the forced swimming test (FST<\/jats:styled-content>). Moreover, 30 days after testicular T<\/jats:styled-content>\/D<\/jats:styled-content>, testicular venous testosterone and serum nitrite concentrations were measured. A correlation was observed between either a decrease in plasma testosterone or an increase in serum nitrite concentrations with prolongation in immobility time in the testicular T<\/jats:styled-content>\/D<\/jats:styled-content>\u2010operated rats FST<\/jats:styled-content>. Minocycline (160 mg\/kg) exerted the highest significant antidepressant\u2010like effect in the operated rats in the FST<\/jats:styled-content> (p<\/jats:italic> < 0.001). Furthermore, combination of subeffective doses of minocycline (80 mg\/kg) and either l<\/jats:sc>\u2010NAME<\/jats:styled-content> (10 mg\/kg) or AG<\/jats:styled-content> (50 mg\/kg) demonstrated a significant robust antidepressant\u2010like activity in T<\/jats:styled-content>\/D<\/jats:styled-content> group (p<\/jats:italic> < 0.01). Consequently, NO<\/jats:styled-content>\/cGMP<\/jats:styled-content> pathway was involved in testicular T<\/jats:styled-content>\/D<\/jats:styled-content>\u2010induced depressive\u2010like behaviour and antidepressant\u2010like activity of minocycline in the animal model. Moreover, a contribution was observed between either decreased testosterone or elevated serum nitrite levels and depressive\u2010like behaviour following testicular T<\/jats:styled-content>\/D<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bcpt.12489","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T15:31:54Z","timestamp":1442590314000},"page":"249-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Minocycline Attenuates Depressive\u2010Like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway"],"prefix":"10.1111","volume":"118","author":[{"given":"Seyed Soheil Saeedi","family":"Saravi","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Tehran 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