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Despite the large number of experiments using animal models for allergic hepatitis, it is still difficult to produce a picture of chronic hepatitis. Therefore, this study was conducted to introduce an animal model approximating to the mechanism of chronicity in human hepatitis. The study also aimed to examine the hepatoprotective effects of curcumin, silybin phytosome<jats:sup>\u00ae<\/jats:sup> and \u03b1\u2010R\u2010lipoic acid against thioacetamide (<jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>)\u2010induced chronic hepatitis in rat model. <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> was administered intraperitoneally at a dose of 200 mg\/kg three times weekly for 4 weeks. At the end of this period, a group of rats was killed to assess the development of chronic hepatitis in comparison with their respective control group. <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> administration was then discontinued, and the remaining animals were subsequently allocated into four groups. Group 1 was left untreated, whereas groups 2\u20134 were allowed to receive daily oral doses of curcumin, silybin phytosome<jats:sup>\u00ae<\/jats:sup> or \u03b1\u2010R\u2010lipoic acid, respectively, for 7 weeks. Increases in hepatic levels of malondialdehyde associated with <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content> administration were inhibited in groups receiving supplements. Furthermore, glutathione depletion, collagen deposition, macrophage activation and nuclear factor \u03baappa\u2010B expression as well as tumour necrosis factor\u2010\u03b1 and interleukin\u20106 levels were significantly decreased in response to supplements administration. Serological analysis of liver function and liver histopathological examination reinforced the results. The above evidence collectively indicates that the antioxidant and anti\u2010inflammatory activities of curcumin, silybin phytosome<jats:sup>\u00ae<\/jats:sup> and \u03b1\u2010R\u2010lipoic acid may confer therapeutic efficacy against chronic hepatitis.<\/jats:p>","DOI":"10.1111\/bcpt.12502","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T20:57:24Z","timestamp":1444769844000},"page":"369-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Curcumin, Silybin Phytosome<sup>\u00ae<\/sup> and \u03b1\u2010R\u2010Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production"],"prefix":"10.1111","volume":"118","author":[{"given":"Shimaa O.","family":"Ali","sequence":"first","affiliation":[{"name":"Biochemistry Department Faculty of Pharmacy Cairo University Cairo 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