{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T11:10:06Z","timestamp":1748689806203,"version":"3.41.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000124","name":"Office of Research on Women's Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["2K12HD043488\u201011"],"award-info":[{"award-number":["2K12HD043488\u201011"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult individuals born with intrauterine growth restriction (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>) have physiological maladaptations that significantly increase risk of chronic disease. We suggested that such abnormalities in organ function would alter pharmacokinetics throughout life, exacerbated by environmental mismatch. Pregnant and lactating rats were fed either a purified control diet (18% protein) or low\u2010protein diet (9% protein) to produce<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>offspring. Offspring were weaned onto either laboratory chow (11% fat) or high\u2010fat diet (45% fat). Adult offspring (5 months old) were dosed with furosemide (10 mg\/kg i.p.) and serum and urine collected. The overall exposure profile in<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>males was significantly reduced due to a ~35% increase in both clearance and volume of distribution. Females appeared resistant to the<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>phenotype. The effects of the high\u2010fat diet trended in the opposite direction to that of<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, with increased drug exposure due to decreases in both clearance (31% males, 46% females) and volume of distribution (24% males, 44% females), with a 10% longer half\u2010life in both genders. The alterations in furosemide pharmacokinetics and pharmacodynamics were explained by changes in the expression of renal organic anion transporters 1 and 3, and sodium\u2013potassium\u2013chloride cotransporter\u20102. In summary, this study suggests that<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>and diet interact to produce subpopulations with similar body\u2010weights but dissimilar pharmacokinetic profiles; this underlines the limitation of one\u2010size\u2010fits\u2010all dosing which does not account for physiological differences in body composition resulting from<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>and diet.<\/jats:p>","DOI":"10.1111\/bcpt.12523","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T14:42:38Z","timestamp":1447080158000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Furosemide Pharmacokinetics in Adult Rats become Abnormal with an Adverse Intrauterine Environment and Modulated by a Post\u2010Weaning High\u2010Fat Diet"],"prefix":"10.1111","volume":"118","author":[{"given":"Barent N.","family":"DuBois","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy Oregon State University\/Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy Oregon State University\/Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy Oregon State University\/Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Center for Developmental Health Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh","family":"Cherala","sequence":"additional","affiliation":[{"name":"Center for Developmental Health Oregon Health &amp; Science University Portland OR USA"},{"name":"Department of Obstetrics &amp; Gynecology School of Medicine Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31829cb9ca"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.4.1066"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09712.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1648-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7010119"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.11.2827"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.013748"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500000118"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0930147"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.01.056"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044160"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.151"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174411000110"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420093278"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.04.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.043117"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0090-9556(25)00282-X","article-title":"Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite\u2010specific assay","volume":"8","author":"Smith DE","year":"1980","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(92)90020-B"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199703)30:2<141::AID-DEV5>3.0.CO;2-Q"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511001127"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.100545"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.192"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1681\/ASN.V72345","article-title":"Role of the kidneys in the metabolism of furosemide: its inhibition by probenecid","volume":"7","author":"Pichette V","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21142"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0022-3565(25)33179-4","article-title":"Nonrenal clearance of furosemide as a cause of diuretic response variability in the rat","volume":"222","author":"Lambert C","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259109039512"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00528.2007"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00524.2013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00604.2007"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12523","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:38:49Z","timestamp":1748687929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,28]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/bcpt.12523"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12523","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"type":"print","value":"1742-7835"},{"type":"electronic","value":"1742-7843"}],"subject":[],"published":{"date-parts":[[2015,12,28]]},"assertion":[{"value":"2015-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}