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On the other hand, nebivolol, a \u03b2<jats:sub>1<\/jats:sub>\u2010adrenoceptor antagonist, exhibits vasodilatory and antioxidative properties. This study aimed to determine whether nebivolol possesses a protective effect against cisplatin nephrotoxicity and explore many mechanisms underlying this potential effect. Nephrotoxicity was induced in Wistar rats by a single intraperitoneal injection of cisplatin (6 mg\/kg) on day 2. Nebivolol (10 mg\/kg) was administered orally for 7 consecutive days. Nebivolol showed a nephroprotective effect as demonstrated by the significant reduction in the elevated levels of serum creatinine and urea as well as renal levels of malondialdehyde, nitric oxide products (nitrite\/nitrate), inducible nitric oxide synthase, tumour necrosis factor\u2010alpha, caspase\u20103, angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and endothelin\u20101 with a concurrent increase in renal levels of reduced glutathione and endothelial nitric oxide synthase compared to untreated rats. Histopathological examination confirmed the nephroprotective effect of nebivolol. Pre\u2010treatment with <jats:italic>N<\/jats:italic><jats:sub>\u03c9<\/jats:sub>\u2010nitro\u2010L\u2010arginine methyl ester, the non\u2010specific nitric oxide synthase inhibitor, partially altered the protection afforded by nebivolol. In conclusion, nebivolol protects rats against cisplatin\u2010induced nephrotoxicity that is most likely through its antioxidant, anti\u2010inflammatory and antiapoptotic effects as well as by abrogation of the augmented angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and endothelin\u20101 levels.<\/jats:p>","DOI":"10.1111\/bcpt.12538","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T12:06:40Z","timestamp":1448885200000},"page":"449-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Nebivolol Ameliorates Cisplatin\u2010Induced Nephrotoxicity in Rats"],"prefix":"10.1111","volume":"118","author":[{"given":"Mohamed A.","family":"Morsy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Clinical Pharmacy King Faisal University Al\u2010Ahsa Saudi Arabia"},{"name":"Department of Pharmacology Faculty of 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