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In the present study, a chronic mild stress (<jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content>) model of male Sprague Dawley rats was used to investigate the role of anti\u2010inflammatory drugs in the treatment of depression. All the animals in different groups, except the normal control group, were exposed to <jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content> procedure for 28 days and concurrently treated with aspirin (10 mg\/kg, p.o.), dexamethasone (1 mg\/kg p.o.) and amitriptyline (10 mg\/kg p.o., reference standard), respectively. Amitriptyline was also used in combination with aspirin and dexamethasone to inspect any synergistic effects. Tests performed towards the end of the study included sucrose preference test, behavioural tests like forced swim test, elevated plus\u2010maze, light\/dark box, locomotor activity and biochemical estimations like serum cortisol and brain neurotransmitters. Disease control group (<jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content>\u2010treated) produced significant depressive behaviour in rats. The animals treated with aspirin showed increased sucrose preference, decreased immobility time in forced swim test, decreased serum cortisol and increased brain serotonin levels signifying antidepressant action. In contrast, there was aggravation of depressive behaviour in rats treated with dexamethasone. Together, these findings suggest that aspirin can serve as a potential antidepressant both individually and as adjunctive agent in the treatment of depression. Inhibition of the inflammatory mediators during stress procedures or any other potential physiological and biochemical mechanisms may be involved in its antidepressant effect.<\/jats:p>","DOI":"10.1111\/bcpt.12539","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T06:37:26Z","timestamp":1449643046000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats"],"prefix":"10.1111","volume":"119","author":[{"given":"Shailendra","family":"Bhatt","sequence":"first","affiliation":[{"name":"L. J. Institute of Pharmacy L.J. Campus Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Shukla","sequence":"additional","affiliation":[{"name":"L. J. Institute of Pharmacy L.J. 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