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Because they are lipid\u2010soluble gases, gaseous transmitters are not constrained by cellular membranes, so that their storage in vesicles for later release is not possible. Gasotransmitter signals are terminated by falling concentrations upon reduction in production that are caused by reacting with cellular components (essentially reactive oxygen species and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), binding to cellular components or diffusing away. <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> and, more recently, H<jats:sub>2<\/jats:sub>S have been identified as key mediators in neurotransmission of the urinary tract, involved in the regulation of ureteral smooth muscle activity and urinary flow ureteral resistance, as well as by playing a crucial role in the smooth muscle relaxation of bladder outlet region. Urinary bladder function is also dependent on integration of inhibitory mediators, such as <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, released from the urothelium. In the bladder base and distal ureter, the co\u2010localization of neuronal <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> synthase with substance P and calcitonin gene\u2010related peptide in sensory nerves as well as the existence of a high nicotinamide adenine dinucleotide phosphate\u2010diaphorase activity in dorsal root ganglion neurons also suggests the involvement of <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> as a sensory neurotransmitter.<\/jats:p>","DOI":"10.1111\/bcpt.12565","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T14:00:14Z","timestamp":1455199214000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of Nitric Oxide and Hydrogen Sulfide in Urinary Tract Function"],"prefix":"10.1111","volume":"119","author":[{"given":"V\u00edtor 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