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Clonidine (<jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content>), a partial \u03b1<jats:sub>2<\/jats:sub>\u2010adrenergic agonist, and mirtazapine (<jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content>), an antagonist of \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor, both clinically aid alcohol withdrawal. Considering different mechanisms of action of the two drugs, this study was designed to see how far these two mechanistically different drugs differ in their ability to decrease the severity of ethanol withdrawal syndrome. The effect of <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> on ethanol withdrawal\u2010induced anxiety, depression and memory impairment was analysed using <jats:styled-content style=\"fixed-case\">EPM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> tests, respectively. Animals received distilled water, ethanol and\/or either of the drugs (<jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content>) in different doses. Relapse to alcohol use was analysed by <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> test. Animals received ethanol as a conditioning drug and distilled water, <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> as test drug. <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> both alleviated anxiety in a dose\u2010dependent manner. <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> (4\u00a0mg\/kg) was more effective than <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> (0.1\u00a0mg\/kg) in ameliorating the anxiogenic effect of alcohol withdrawal. However, <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> treatment increased depression. It significantly decreased swimming time and increased immobility time, whereas <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> treatment decreased immobility time and increased climbing and swimming time during abstinence. The effect was dose dependent for both drugs. The results of <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> test show that <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> treatment worsens working memory. Significant increase in <jats:styled-content style=\"fixed-case\">SDE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TSZ<\/jats:styled-content> and decrease in <jats:styled-content style=\"fixed-case\">SDL<\/jats:styled-content> were observed in <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content>\u2010treated animals. <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> treatment, on the other hand, improved working memory at both doses. Further, both <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> alleviated craving. A significant decrease in time spent in the ethanol\u2010paired chamber was seen. <jats:styled-content style=\"fixed-case\">MRT<\/jats:styled-content> treatment at both doses showed better effect than <jats:styled-content style=\"fixed-case\">CLN<\/jats:styled-content> in preventing the development of preference in <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> test. These findings indicate a potential therapeutic use and better profile of mirtazapine over clonidine in improving memory, as well as in alleviating depression, anxiety and craving associated with alcohol withdrawal.<\/jats:p>","DOI":"10.1111\/bcpt.12566","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T13:59:46Z","timestamp":1455199186000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Evaluation of Partial \u03b1<sub>2<\/sub>\u2010Adrenoceptor Agonist and Pure \u03b1<sub>2<\/sub>\u2010Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice"],"prefix":"10.1111","volume":"119","author":[{"given":"Shivani","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Jamia Hamdard University New Delhi 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