{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:20:23Z","timestamp":1792588823454,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universidad Andres Bello"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuropathic pain is the result of injury to the nervous system, and different animal models have been established to meet the manifestations of neuropathy. The pharmacotherapy for neuropathic pain includes gabapentin and tramadol, but these are only partially effective when given alone. The aim of this study was to assess the antinociceptive interaction between both drugs using the isobolographic analysis and changes of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 concentration in a mouse model of neuropathic pain (partial sciatic nerve ligation or <jats:styled-content style=\"fixed-case\">PSNL<\/jats:styled-content>). The i.p. administration of gabapentin (5\u2013100 mg\/kg) or tramadol (12.5\u2013100 mg\/kg) displayed a dose\u2010dependent antinociception in the hot plate assay of <jats:styled-content style=\"fixed-case\">PSNL<\/jats:styled-content> mice, and effects induced by gabapentin with tramadol were synergistic. Administration of gabapentin or tramadol reversed significantly the increase in the concentration of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 induced by <jats:styled-content style=\"fixed-case\">PSNL<\/jats:styled-content> after either 7 or 14 days and their combination was significantly more potent in reversing the elevated concentration of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2. The synergism obtained by the co\u2010administration of gabapentin and tramadol is proposed to result from action on different mechanisms in pain pathways. Gabapentin or tramadol or their combination modulates the expression of pro\u2010inflammatory cytokine, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, in a model of mice <jats:styled-content style=\"fixed-case\">PSNL<\/jats:styled-content> which could be due to an inhibition of glial function.<\/jats:p>","DOI":"10.1111\/bcpt.12567","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T13:59:45Z","timestamp":1455199185000},"page":"210-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain"],"prefix":"10.1111","volume":"119","author":[{"given":"Hugo F.","family":"Miranda","sequence":"first","affiliation":[{"name":"Faculty of Medicine School of Pharmacy Andres Bello University Santiago Chile"},{"name":"Pharmacology Program ICBM Faculty Santiago Chile of Medicine University of Chile Santiago 7 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Noriega","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Pharmacy Andres Bello University Santiago Chile"},{"name":"Cardiovascular Department Clinic Hospital University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Prieto","sequence":"additional","affiliation":[{"name":"Pharmacology Program ICBM Faculty Santiago Chile of Medicine University of Chile Santiago 7 Chile"},{"name":"Cardiovascular Department Clinic Hospital University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Zanetta","sequence":"additional","affiliation":[{"name":"Pharmacology Program ICBM Faculty Santiago Chile of Medicine University of Chile Santiago 7 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Castillo","sequence":"additional","affiliation":[{"name":"Physiophathology Program ICBM Faculty of Medicine University of Chile Santiago 7 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Aranda","sequence":"additional","affiliation":[{"name":"Pharmacology Program ICBM Faculty Santiago Chile of Medicine University of Chile Santiago 7 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Sierralta","sequence":"additional","affiliation":[{"name":"Pharmacology Program ICBM Faculty Santiago Chile of Medicine University of Chile Santiago 7 Chile"},{"name":"Faculty of Odontology Universidad Finis Terrae Providencia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12261"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.10.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.01.022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.13223FP"},{"key":"e_1_2_9_7_1","first-page":"4.CD007938","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","volume":"74","author":"Moore RA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0649"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-27"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(11)60074-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000149"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000143"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00045-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00746.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.11.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1201\/9781420036107","volume-title":"Drug Synergism and Dose\u2010Efect Data Analysis","author":"Tallarida RJ","year":"2000"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00404-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.04.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355071"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-014-0062-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i3.432"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1251"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1992"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2840-11.2011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.018"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12567","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:31:13Z","timestamp":1696318273000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,15]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/bcpt.12567"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12567","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,15]]},"assertion":[{"value":"2015-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}