{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:29:58Z","timestamp":1766428198050},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although our previous study revealed an association between prolactin level and risperidone dosage, data regarding the plasma concentration of risperidone are lacking. Therefore, this study aimed to investigate the association between plasma drug concentrations of risperidone, 9\u2010hydroxyrisperidone and serum prolactin level in Thai children and adolescents with autism spectrum disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>). The individuals for this study were 103 children and adolescents with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> (90 males and 13 females). In the 12th hour after the last risperidone dose, blood samples were collected for analysis. Serum prolactin, plasma risperidone and 9\u2010hydroxyrisperidone levels were measured. Patients' clinical data were collected from medical records \u2013 age, weight, height, body mass index, dose of risperidone and duration of treatment. Serum prolactin level was significantly positively correlated with plasma 9\u2010hydroxyrisperidone level (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = 0.355, <jats:italic>p<\/jats:italic> &lt; 0.001). The median concentration of 9\u2010hydroxyrisperidone in individuals with hyperprolactinaemia (7.59 ng\/ml; <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 4.86\u201315.55) was significantly higher than non\u2010hyperprolactinaemic individuals (5.18 ng\/ml; <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 2.10\u20138.99) after risperidone treatment (<jats:italic>p<\/jats:italic> = 0.006). By multivariate analysis, high prolactin level was correlated to high 9\u2010hydroxyrisperidone level (<jats:italic>p<\/jats:italic> = 0.010). The results of this study showed that serum prolactin levels, especially in autistic individuals with hyperprolactinaemia during risperidone treatment, were significantly correlated with the level of 9\u2010hydroxyrisperidone. These results suggest that hyperprolactinaemia may develop during risperidone treatment.<\/jats:p>","DOI":"10.1111\/bcpt.12570","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T09:06:39Z","timestamp":1455613599000},"page":"267-272","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["9\u2010Hydroxyrisperidone\u2010Induced Hyperprolactinaemia in Thai Children and Adolescents with Autism Spectrum Disorder"],"prefix":"10.1111","volume":"119","author":[{"given":"Nattawat","family":"Ngamsamut","sequence":"first","affiliation":[{"name":"Yuwaprasart Waithayopathum Child and Adolescent Psychiatric Hospital Department of Mental Health Services Ministry of Public Health Samut Prakan Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaowaluck","family":"Hongkaew","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine 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