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To examine whether certain genotypes were associated with this, we examined the frequencies of 29 SNP<\/jats:styled-content>s located in candidate genes related to opioid pharmacology: ABCB<\/jats:styled-content>1<\/jats:italic>, OPRM<\/jats:styled-content>1<\/jats:italic>, UGT<\/jats:styled-content>2B7<\/jats:italic>, CYP<\/jats:styled-content>3A5<\/jats:italic>, CYP<\/jats:styled-content>2B6<\/jats:italic>, CYP<\/jats:styled-content>2C19<\/jats:italic>, CYP<\/jats:styled-content>2D6<\/jats:italic>, COMT<\/jats:styled-content><\/jats:italic>, KCNJ<\/jats:styled-content>6<\/jats:italic> and SCN<\/jats:styled-content>9A<\/jats:italic> in 274 deceased patients with OA<\/jats:styled-content> (DOA<\/jats:styled-content>), 309 living patients with OA<\/jats:styled-content> (LOA<\/jats:styled-content>) and in 394 healthy volunteers (HV<\/jats:styled-content>). The main hypothesis of the study was that subjects homozygous for the variant 3435T<\/jats:italic> in ABCB<\/jats:styled-content>1<\/jats:italic> (rs1045642) occur more frequently in DOA<\/jats:styled-content> than in LOA<\/jats:styled-content> and HV<\/jats:styled-content> because morphine and methadone more readily cross the blood barrier in these subjects due to a lower efflux transporter activity of the ABCB<\/jats:styled-content>1 (p\u2010glycoprotein) transporter. Our results did not support this hypothesis, because no statistically significant difference (p<\/jats:italic> = 0.506) in the frequency of the TT<\/jats:styled-content><\/jats:italic> genotype of rs1045642 was observed between the DOA<\/jats:styled-content>, LOA<\/jats:styled-content> and HV<\/jats:styled-content> cohorts. However, for another ABCB<\/jats:styled-content>1<\/jats:italic> variant, rs9282564, we found that the frequencies of the AG<\/jats:styled-content> and TT<\/jats:styled-content><\/jats:italic> genotypes were 13, 21 and 25% in DOA<\/jats:styled-content>, LOA<\/jats:styled-content> and HV<\/jats:styled-content>, respectively, and after correcting for age, sex and multiple testing, the differences between DOA<\/jats:styled-content> and LOA<\/jats:styled-content> were statistically significantly different (p<\/jats:italic> = 0.027). The COMT<\/jats:styled-content><\/jats:italic> rs4680 AA<\/jats:styled-content><\/jats:italic> genotype frequencies were 25%, 35% and 31% in DOA<\/jats:styled-content>, LOA<\/jats:styled-content> and HV<\/jats:styled-content>, respectively, and the difference between DOA<\/jats:styled-content> and LOA<\/jats:styled-content> was also statistically significant (p<\/jats:italic> = 0.0028). In conclusion, this study generated two hypotheses suggesting possible associations of a reduced risk of death and carrying, respectively, the ABCB<\/jats:styled-content>1<\/jats:italic> rs9282564 AG<\/jats:styled-content> and TT<\/jats:styled-content><\/jats:italic> genotypes and the COMT<\/jats:styled-content><\/jats:italic> rs4680 AA<\/jats:styled-content><\/jats:italic> genotype among patients with OA<\/jats:styled-content>. These findings should be confirmed in independent cohorts, and if a causal relationship between these variants and fatal poisoning in OA<\/jats:styled-content> is confirmed, then it may be possible at least in theory<\/jats:italic> to personalize prevention of sudden death in this patient group.<\/jats:p>","DOI":"10.1111\/bcpt.12602","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:47:04Z","timestamp":1460314024000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The ABCB<\/scp>1<\/i>, rs9282564, AG<\/scp><\/i> and TT<\/scp><\/i> Genotypes and the COMT<\/scp>,<\/i> rs4680, AA<\/scp><\/i> Genotype are Less Frequent in Deceased Patients with Opioid Addiction than in Living Patients with Opioid Addiction"],"prefix":"10.1111","volume":"119","author":[{"given":"Dorte J.","family":"Christoffersen","sequence":"first","affiliation":[{"name":"Institute of Forensic Medicine University of Southern Denmark Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Damkier","sequence":"additional","affiliation":[{"name":"Department of Public Health Clinical Pharmacology University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Chemistry & Pharmacology Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Feddersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry & Pharmacology Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"OPEN \u2010 Odense Patient data Explorative Network Odense University Hospital and Department of Clinical Research University of Southern Denmark Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen L.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine University of Southern Denmark Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Brasch\u2010Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Br\u00f8sen","sequence":"additional","affiliation":[{"name":"Department of Public Health Clinical Pharmacology University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"The United Nations Office on Drugs and Crime (UNODC) World Drug Report Annual report 2015.https:\/\/www.unodc.org\/documents\/wdr2015\/World_Drug_Report_2015.pdf(last accessed on 14 september 2015)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.5.503"},{"key":"e_1_2_8_4_1","unstructured":"TjagvadC PetersenH ThylstrupB BiongS ClausenT.Intoxication deaths and other narcotic\u2010related deaths in Denmark 2008\u201011. 2014. 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