{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:01:02Z","timestamp":1782010862612,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Science and Technology Project of Zhengjiang Province","award":["2016ZB032"],"award-info":[{"award-number":["2016ZB032"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxymatrine (<jats:styled-content style=\"fixed-case\">OMT<\/jats:styled-content>) is a traditional Chinese medicine monomer and has been used for the treatment of chronic viral hepatitis and many other diseases. We aimed to investigate whether <jats:styled-content style=\"fixed-case\">OMT<\/jats:styled-content> could induce hepatotoxicity in mice and explored the preliminary mechanisms of toxic effects. Twenty\u2010four Institute for Cancer Research male mice were randomly divided into four groups: control group, 40, 160 and 320 mg\/kg <jats:styled-content style=\"fixed-case\">OMT<\/jats:styled-content>\u2010treated group. <jats:styled-content style=\"fixed-case\">OMT<\/jats:styled-content> was orally administered once daily for 7 days. The <jats:styled-content style=\"fixed-case\">OMT<\/jats:styled-content>\u2010treated group exhibited an improved liver index and increase in serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase,augmented liver histological injury, elevated levels of malondialdehyde and tumour necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) accompanied by the activation of caspase\u20109\/\u20108\/\u20103, up\u2010regulated expressions of tumour necrosis factor receptor l (<jats:styled-content style=\"fixed-case\">TNFR<\/jats:styled-content>1), <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> receptor\u2010associated structure domain (<jats:styled-content style=\"fixed-case\">TRADD<\/jats:styled-content>) and phosphorylation of stress\u2010activated protein kinase\/c\u2010jun N\u2010terminal protein kinases (p\u2010<jats:styled-content style=\"fixed-case\">SAPK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>). Altogether, these results suggest that <jats:styled-content style=\"fixed-case\">OMT<\/jats:styled-content> at a dose of 320 mg\/kg leads to liver damage and is related to the activation of <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content> signalling pathway mediated by <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 in the liver of mice.<\/jats:p>","DOI":"10.1111\/bcpt.12608","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T12:36:41Z","timestamp":1461242201000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Oxymatrine Induces Liver Injury through <scp>JNK<\/scp> Signalling Pathway Mediated by <scp>TNF<\/scp>\u2010\u03b1 <i>In Vivo<\/i>"],"prefix":"10.1111","volume":"119","author":[{"given":"Hong","family":"Lu","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang Chinese 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