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It is desirable to have robust arthritis models in B6 mice, as many transgene strains are bred on this background. However, several of the most widely used mouse model of arthritis cannot be induced in B6 mice without the drawback of lower incidence, reduced severity and higher variation, if at all. <jats:styled-content style=\"fixed-case\">DTHA<\/jats:styled-content> is induced by modifying a classical methylated bovine serum albumin (<jats:styled-content style=\"fixed-case\">mBSA<\/jats:styled-content>)\u2010induced <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> response by administering a cocktail of anti\u2010type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> collagen antibodies (anti\u2010<jats:styled-content style=\"fixed-case\">CII<\/jats:styled-content>) between immunization and challenge. Arthritis affects one, predefined paw in which acute inflammation and severe arthritis rapidly develop and peak after 4\u20137 days. Disease is self\u2010resolving over the course of around 3 weeks. Disease manifestations resemble those seen in other arthritis models and include bone erosion, cartilage destruction, oedema, pannus and new bone formation. Induction of <jats:styled-content style=\"fixed-case\">DTHA<\/jats:styled-content> is dependent on <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells while B cells are dispensable. The <jats:styled-content style=\"fixed-case\">DTHA<\/jats:styled-content> model is set apart from other murine arthritis models in that it can be induced in B6 mice with 100% incidence and with high and consistent severity. This is the clearest advantage of the model, as the mechanisms of disease and clinical manifestations can be found in other arthritis models. The model holds potential for future modifications that may improve the lack of chronicity.<\/jats:p>","DOI":"10.1111\/bcpt.12657","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T11:38:43Z","timestamp":1472038723000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacological Value of Murine Delayed\u2010type Hypersensitivity Arthritis: A Robust Mouse Model of Rheumatoid Arthritis in C57<scp>BL<\/scp>\/6 Mice"],"prefix":"10.1111","volume":"120","author":[{"given":"Sara Marie","family":"Atkinson","sequence":"first","affiliation":[{"name":"Novo Nordisk &amp; LIFE <i>In Vivo<\/i> Pharmacology Centre &amp; the Danish <i>In Vivo<\/i> Pharmacology PhD Program University of Copenhagen Frederiksberg C Denmark"},{"name":"Diabetes Complications Research Novo Nordisk A\/S Maaloev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneline","family":"Nansen","sequence":"additional","affiliation":[{"name":"Pharmacology Zealand Pharma Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60008-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81109-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27503"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.03.047"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148551"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.19"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2005.06.017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.3.321"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03354.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3867"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-0931-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.022905"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2089"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.12.7694"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1031888"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24767"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0531-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4096"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2012.08.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38404"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/283666a0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202055"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.173"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200314"},{"key":"e_1_2_8_27_1","first-page":"224","article-title":"Electrical charge of the antigen determines its localization in the mouse knee joint. 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