{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:52:16Z","timestamp":1780073536226,"version":"3.54.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iron\u2010overloaded \u03b2\u2010thalassaemia major (<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>) children have high risk of delayed sexual\/physical maturation, liver\/heart diseases and reduced life expectancy. The lifelong need to use iron chelators, their unpleasant administration, side effects and lack of awareness regarding iron overload risks all hamper <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> patient compliance to iron chelators. This study evaluated the impact of clinical pharmacist\u2010provided services on the outcome of iron\u2010overloaded <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> children. Forty\u2010eight <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> children were randomly assigned to either control group, who received standard medical care, or intervention group, who received standard medical care plus clinical pharmacist\u2010provided services. Services included detection of drug\u2010related problems (<jats:styled-content style=\"fixed-case\">DRP<\/jats:styled-content>s) and their management, patient education regarding disease nature and iron chelators, as well as providing patient\u2010tailored medication charts. After six months of study implementation, there was a highly significant difference between the control and intervention groups in serum ferritin (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>) (mean: 3871 <jats:italic>versus<\/jats:italic> 2362, \u03bcg\/l, <jats:italic>p<\/jats:italic> = 0.0042), patient healthcare satisfaction (median: 24.47 <jats:italic>versus<\/jats:italic> 90.29, <jats:italic>p<\/jats:italic> &lt; 0.0001) and quality of life (QoL) (median: 49.84 <jats:italic>versus<\/jats:italic> 63.51, <jats:italic>p<\/jats:italic> = 0.0049). The intervention group showed a decline from baseline to the end of study in <jats:styled-content style=\"fixed-case\">DRP<\/jats:styled-content>s (64\u20134), the number of non\u2010compliant patients (24\u20133) and mean <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> levels (3949\u20132362 \u03bcg\/l, <jats:italic>p<\/jats:italic> &lt; 0.0001). Clinical pharmacist\u2010provided services can positively impact the outcome of <jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content> children.<\/jats:p>","DOI":"10.1111\/bcpt.12695","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T10:28:04Z","timestamp":1487240884000},"page":"354-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Pharmacist\u2010Provided Services In Iron\u2010Overloaded Beta\u2010Thalassaemia Major Children: A New Insight Into Patient Care"],"prefix":"10.1111","volume":"120","author":[{"given":"Salma M.","family":"Bahnasawy","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Ain\u2010Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia M.","family":"El Wakeel","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Ain\u2010Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagham El","family":"Beblawy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ain\u2010Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"El\u2010Hamamsy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Ain\u2010Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_6_4_1","volume-title":"Disease Control Priorities in Developing Countries","author":"Weatherall D"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630260903346395"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3167"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32835f5a5c"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-11"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01207.x"},{"key":"e_1_2_6_10_1","first-page":"64","article-title":"Iron overload and iron chelation therapy in pediatric patients","volume":"2","author":"Vichinsky E","year":"2009","journal-title":"US Hematol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1438"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155206070412"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-014-9939-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2042-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1543-5946(04)90002-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488412803305795"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730050-00003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043382576"},{"key":"e_1_2_6_19_1","volume-title":"Pharmaceutical Care Practice: The Clinician's Guide","author":"Cipolle RJ","year":"2004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2326-12-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.2152"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-113"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0927-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02357-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203853"},{"key":"e_1_2_6_26_1","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna\u2010Pignatti C","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310902"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2007.02150.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.065"},{"key":"e_1_2_6_30_1","first-page":"141","volume-title":"Pharmaceutical Care Practice: the Patient\u2010Centered Approach to Medication Management Services","author":"Cipolle RJ","year":"2012"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2010.03.011"},{"key":"e_1_2_6_32_1","first-page":"328","article-title":"Iron overload in Beta thalassaemia major and intermedia patients","volume":"8","author":"Mishra AK","year":"2013","journal-title":"Maedica (Buchar)"},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1182\/blood.V43.4.581.581","article-title":"Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children","volume":"43","author":"Siimes MA","year":"1974","journal-title":"Blood"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2011.01224.x"},{"key":"e_1_2_6_35_1","first-page":"1281","article-title":"Quality of life among children with beta\u2010thalassemia major treated in Western Saudi Arabia","volume":"34","author":"Ayoub MD","year":"2013","journal-title":"Saudi Med J"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2326-10-1"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/10410236.2011.616632"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:05:25Z","timestamp":1696338325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/bcpt.12695"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12695","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,16]]},"assertion":[{"value":"2016-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}