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Intravenous doses of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> reduced blood pressure in a dose\u2010dependent fashion (1, 3, 4, 8 and 10 mg\/kg) in both <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> and Wistar Kyoto rats. <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> (10<jats:sup>\u22128<\/jats:sup> to 3 \u00d7 10<jats:sup>\u22123<\/jats:sup> M) induced vasorelaxation in isolated superior mesenteric artery rings of <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> in the presence (n = 7) or absence (n = 8) of functional endothelium [maximum effect (<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>) = 104 \u00b1 3 <jats:italic>versus<\/jats:italic> 103 \u00b1 4%]. After exposure to <jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>l (60 <jats:styled-content style=\"fixed-case\">mM<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> also induced concentration\u2010dependent vasorelaxation (n = 7) compared to that under Phe\u2010induced contraction (<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> = 113.5 + 5.1 <jats:italic>versus<\/jats:italic> 104.5 + 4.0%). Furthermore, <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\u2010induced vasorelaxation in vessels contracted with S(\u2212)\u2010BayK8644 (200 <jats:styled-content style=\"fixed-case\">nM<\/jats:styled-content>), a L\u2010type Ca<jats:sup>2+<\/jats:sup> channel agonist (<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> = 91.4 + 4.3 <jats:italic>versus<\/jats:italic> 104.5 + 4.0%, n = 7). Lastly, <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> (10<jats:sup>\u22123<\/jats:sup> M) reduced <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>\u2010dependent superoxide accumulation in the heart (18 \u00b1 1 <jats:italic>versus<\/jats:italic> 25 \u00b1 1 <jats:styled-content style=\"fixed-case\">MLU<\/jats:styled-content>\/min\/\u03bcg protein, n = 4, <jats:italic>p<\/jats:italic> &lt; 0.05) and kidney (82 \u00b1 3 <jats:italic>versus<\/jats:italic> 99 \u00b1 4 <jats:styled-content style=\"fixed-case\">MLU<\/jats:styled-content>\/min\/\u03bcg protein, n = 4, <jats:italic>p<\/jats:italic> &lt; 0.05). Our data show that <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> reduces blood pressure in normotensive and hypertensive rats. In <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>, this effect might involve Ca<jats:sup>+2<\/jats:sup> channels in the resistance vessels and by its capability of reducing oxidative stress in heart and kidneys.<\/jats:p>","DOI":"10.1111\/bcpt.12700","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T15:56:05Z","timestamp":1478534165000},"page":"348-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats"],"prefix":"10.1111","volume":"120","author":[{"given":"Naiane Ferraz Bandeira","family":"Alves","sequence":"first","affiliation":[{"name":"Biotechnology Center Federal University of Paraiba Jo\u00e3o Pessoa PB Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thyago Moreira","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"Biotechnology Center Federal University of Paraiba Jo\u00e3o Pessoa PB Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de Almeida Travassos","sequence":"additional","affiliation":[{"name":"Biotechnology Center Federal University of Paraiba Jo\u00e3o Pessoa PB Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marciane","family":"Magnani","sequence":"additional","affiliation":[{"name":"Technology Center Federal University of Para\u00edba Jo\u00e3o Pessoa PB Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir","family":"de Andrade Braga","sequence":"additional","affiliation":[{"name":"Biotechnology Center Federal University of Paraiba Jo\u00e3o Pessoa PB Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2014-0351"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11746-014-2562-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-016-0577-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201520140166"},{"key":"e_1_2_8_6_1","first-page":"156","article-title":"Saturated fatty acid composition of human milk in Israel: a comparison between Jewish and Bedouin women","volume":"15","author":"Silberstein T","year":"2013","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1139\/y93-078"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.01.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.10.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.5.1146"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.020107"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/63.6.897"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2011007500088"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"H926","DOI":"10.1152\/ajpheart.00259.2015","article-title":"\u03b1\u2010Lipoic acid reduces neurogenic hypertension by blunting oxidative stress\u2010mediated increase in ADAM17","volume":"309","author":"Queiroz TM","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.12.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/629329"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.971383"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199406000-00012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)90060-2"},{"key":"e_1_2_8_21_1","first-page":"H561","article-title":"Vasorelaxant effects of short chain fatty acid salts in rat caudal artery","volume":"261","author":"Nutting CW","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.05.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/372231a0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703754"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2012.05679.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2013-0091"},{"key":"e_1_2_8_27_1","first-page":"12997","article-title":"Quercetin improves baroreflex sensitivity in spontaneously hypertensive rats","volume":"17","author":"Monteiro MM","year":"2012","journal-title":"Mol Basel Switz"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13511"}],"container-title":["Basic &amp; 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