{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:54:13Z","timestamp":1776128053760,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hacettepe University Scientific Research Projects Coordination Unit","award":["HU.09.D06.101.005"],"award-info":[{"award-number":["HU.09.D06.101.005"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) is a systemic autoimmune disorder. Cytochrome P450 enzymes (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>s) are responsible for various drug metabolism reactions as well as those of endogenous substances which may be associated with autoimmune disease susceptibility. Recently, we reported that in patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C9 seems to be down\u2010regulated due to inflammation. In the same Turkish patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, we investigated whether also<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 activity is decreased. Lansoprazole (30\u00a0mg) was given as a probe drug to evaluate<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 activity in 59 patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>and 27 healthy control volunteers. An<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>method was used to determine plasma lansoprazole and its metabolite, 5\u2010hydroxy lansoprazole, concentrations. The genotyping for<jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 *2, *3<\/jats:italic>and<jats:italic>*17<\/jats:italic>polymorphisms was made using<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content>. The median lansoprazole\/5\u2010hydroxy lansoprazole metabolic ratio (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) in patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>was 2.6\u2010fold higher as compared to the healthy control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, 22.6 (1.3\u201326) and 8.8 (0.5\u2013140) as median and range, respectively). The<jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19*17*17<\/jats:italic>genotype frequency was found to be significantly less in the<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>group as compared to the healthy controls (1.7%<jats:italic>versus<\/jats:italic>14.8% in controls,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). Additionally, colchicine treatment did not affect the<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 enzyme activity in six patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.43). In conclusion, the patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>had lower<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 enzyme activity and lower frequency of the<jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19*17<\/jats:italic>allele as compared to those of the healthy controls. Further studies are warranted on the mechanisms underlying this relation. This study should also be applied to other autoimmune diseases similarly characterized by local or systemic inflammation.<\/jats:p>","DOI":"10.1111\/bcpt.12710","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T17:21:44Z","timestamp":1479835304000},"page":"266-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Decreased Activity and Genetic Polymorphisms of<scp>CYP<\/scp>2C19 in Beh\u00e7et's Disease"],"prefix":"10.1111","volume":"121","author":[{"given":"Mustafa Tugrul","family":"Goktas","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Hacettepe University Ankara Turkey"},{"name":"Department of Medical Pharmacology Faculty of Medicine Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragip Ozgur","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Kalkisim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokman","family":"Cevik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Akdogan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melih O.","family":"Babaoglu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atilla","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine BAU International University Batumi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Bertilsson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Division of Clinical Pharmacology at Karolinska Institutet Karolinska University Hospital Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit","family":"Yasar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"286783","article-title":"Pathophysiological relationship between infections and systemic vasculitis","volume":"2015","author":"Munoz\u2010Grajales C","year":"2015","journal-title":"Autoimmune Dis"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.62.725.151"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01893.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.6.423"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2004.02.008"},{"key":"e_1_2_6_8_1","first-page":"493015","article-title":"Pathophysiology of the Behcet's disease","volume":"2012","author":"Tursen U","year":"2012","journal-title":"Patholog Res Int"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530902843483"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03104.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2004.pto950101.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100358"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0835-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0529-z"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00050-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00835.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00019.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1993.tb04204.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1515\/dmdi-2014-0029","article-title":"Pharmacogenetics of drug oxidation via cytochrome P450 (CYP) in the populations of Denmark, Faroe Islands and Greenland","volume":"30","author":"Brosen K","year":"2015","journal-title":"Drug Metab Pers Ther"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1151-z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.015511"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1899-7"},{"key":"e_1_2_6_23_1","first-page":"1078","article-title":"International study group for Behcet's disease","volume":"335","author":"Criteria for diagnosis of Behcet's disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)72025-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.10.002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2004.950302.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531743"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0820-7"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.3.182"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.151"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.02957.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1050-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.10.007"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.47102\/annals-acadmedsg.V33N5p596","article-title":"Serum interleukin\u20102, interleukin\u20106, tumour necrosis factor\u2010alpha and nitric oxide levels in patients with Behcet's disease","volume":"33","author":"Akdeniz N","year":"2004","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2002.127773"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2007.00417.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.103860"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2333(02)00004-8"},{"key":"e_1_2_6_39_1","first-page":"43","article-title":"Effect of colchicine on rat hepatic cytochrome P450 enzymes by cocktail probe drugs","volume":"69","author":"Xu BB","year":"2014","journal-title":"Pharmazie"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12710","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T19:08:31Z","timestamp":1718910511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/bcpt.12710"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12710","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]},"assertion":[{"value":"2016-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}