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Here, we investigated whether diclofenac (non\u2010selective inhibitor of cyclooxygenase\u20101 and 2,<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102), celecoxib (selective<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 inhibitor) or<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>560 (selective<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101 inhibitor) interact variably with haemodynamic effects of<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>in conscious female rats. Changes caused by<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>(10 mg\/kg i.v.) in blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>),<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>) and myocardial contractility were assessed in the absence and presence of individual<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s (10 mg\/kg each). Compared with vehicle values,<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>caused immediate and sustained (i) increases in<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>and decreases in pulse pressure index (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) and<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, (ii) elevations in left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) contractility (d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub>) and isovolumic relaxation constant (\u03a4au) and (iii) increases in the time\u2010 and frequency\u2010domain indices of<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>and shifted the cardiac sympathovagal balance towards parasympathetic dominance.<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>hypertension was abolished in rats pre\u2010treated with celecoxib and intensified in the presence of diclofenac or<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>560. Alternatively, the<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>\u2010evoked decreases in<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, increases in<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>indices and cardiac parasympathetic dominance were blunted by celecoxib in contrast to no effect for diclofenac or<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>560. Similarly, celecoxib, but not other<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s, eliminated the elevated<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>contractility (d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub>) and isovolumic relaxation constant (\u03a4au, \u03c4), which reflect cardiac systolic and diastolic function, respectively, that accompanied the<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>\u2010induced pressure load. The data underscore the preferential capacity of selective<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 inhibition by celecoxib to mitigate<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>hypertension and consequent alterations in cardiac performance and autonomic balance. By contrast,<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>effects are preserved or even exacerbated after<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101 inhibition.<\/jats:p>","DOI":"10.1111\/bcpt.12754","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T12:52:42Z","timestamp":1483620762000},"page":"571-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Opposite Modulatory Effects of Selective and Non\u2010Selective Cyclooxygenase Inhibition on Cardiovascular and Autonomic Consequences of Cyclosporine in Female Rats"],"prefix":"10.1111","volume":"120","author":[{"given":"Karim S.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed 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