{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T03:00:45Z","timestamp":1717124445159},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The primary objective of our study was to evaluate the frequency of suspected heparin\u2010induced thrombocytopenia (<jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content>) among patients treated with different formulations of heparin and investigate the factors that affect the incidence of <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content>. This study is an electronic medical record (<jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>)\u2010based large\u2010scale retrospective cohort study conducted from 2009 to 2014 in Korea. After hospitalization, patient platelet count was determined before heparin was prescribed, and all platelet count values obtained during hospitalization were extracted. Suspected <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> was estimated by three 4Ts scores (acute thrombocytopenia, timing onset and other possible causes), which when combined yielded a high probability of <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content>. Among 6046 patients enrolled in this study, <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> was suspected in 641 cases (10.6%) and a statistically significant increase in <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> incidence rate was observed for three heparins used (<jats:italic>p<\/jats:italic> &lt; 0.001). Dalteparin (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> = 0.55, <jats:italic>p<\/jats:italic> = 0.036) and enoxaparin (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> = 0.40, <jats:italic>p<\/jats:italic> &lt; 0.001) showed a relatively low <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> incidence rate, compared to unfractionated heparin. Majority of suspected <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> cases (76.9 and 66.7%) occurred in days 8\u201310 and 5\u20137 of dalteparin and enoxaparin treatments, respectively. Most of the patients medicated with dalteparin were cancer patients; however, no statistically significant relationship was observed between <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> occurrence and cancer. <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> can cause serious complications, making early diagnosis crucial. Clinical practitioners first prescribing heparin should focus on preventing and detecting complications early by conducting frequent, regular platelet counts before and after heparin administration.<\/jats:p>","DOI":"10.1111\/bcpt.12791","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:25:51Z","timestamp":1491409551000},"page":"360-367","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative Analysis of the Suspected Heparin\u2010Induced Thrombocytopenia Level in Korea"],"prefix":"10.1111","volume":"121","author":[{"given":"Hun\u2010Sung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medical Informatics College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunah","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Sookmyung Women's University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunyong","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Research Coordinating Center Catholic Medical Center The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Woo","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji il","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Vascular and Transplant Surgery Department of Surgery College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Sung","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Vascular and Transplant Surgery Department of Surgery College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang\u2010Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Vascular and Transplant Surgery Department of Surgery College of Medicine The Catholic University of Korea Seoul 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