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Drug\u2013drug interaction of gemfibrozil and other <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b1 agonists has been reported. However, the role of <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b1 in cytochrome P450 (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>) induction by fibrates is not well known. In this study, wild\u2010type mice were first fed gemfibrozil\u2010containing diets (0.375%, 0.75% and 1.5%) for 14 days to establish a dose\u2013response relationship for <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content> induction. Then, wild\u2010type mice and <jats:italic>Ppar<\/jats:italic>\u03b1\u2010null mice were treated with a 0.75% gemfibrozil\u2010containing diet for 7 days. <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3a, <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2b and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2c were induced in a dose\u2010dependent manner by gemfibrozil. In <jats:italic>Ppar<\/jats:italic>\u03b1\u2010null mice, their <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level, protein level and activity were induced more than those in wild\u2010type mice. So, gemfibrozil induced <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>, and this action was inhibited by activated <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b1. These data suggested that the induction potential of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>s was suppressed by activated <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b1, showing a potential role of this receptor in drug\u2013drug interactions and metabolic diseases treated with fibrates.<\/jats:p>","DOI":"10.1111\/bcpt.12794","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:26:52Z","timestamp":1491409612000},"page":"169-174","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Peroxisome Proliferator\u2010Activated Receptor \u03b1 Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil"],"prefix":"10.1111","volume":"121","author":[{"given":"Cunzhong","family":"Shi","sequence":"first","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine 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