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AZL antagonizes the AT<jats:sub>1<\/jats:sub> receptor for angiotensin II (ANG II), whereas angiotensin\u2010converting enzyme inhibitors block the conversion of angiotensin I to ANG II, but not alternative routes of formation of ANG II. The bioavailability of AZL is about 60% and it has a <jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub> of 1.5\u20133\u00a0hr and a half\u2010life of approximately 11\u00a0hr. With its IC<jats:sub>50<\/jats:sub> of 7.4\u00a0nM after 5\u00a0hr of drug washout in radioligand assays, AZL has a tighter and longer\u2010lasting binding to the AT<jats:sub>1<\/jats:sub> receptor by several orders of magnitude than other ARBs, which might lead to a more effective reduction in BP. Clinical studies have revealed that AZL doses of 40 and 80\u00a0mg\/day reduce BP significantly better than maximal clinical doses of valsartan or olmesartan, while being well tolerated and exhibiting a spectrum of adverse effects comparable to those of other ARBs. These properties of AZL might lower the risk of cardiovascular disease and thereby reduce mortality rates. However, the existing mortality studies have not found this correlation, which should be further investigated.<\/jats:p>","DOI":"10.1111\/bcpt.12800","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T15:37:18Z","timestamp":1493221038000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Azilsartan Medoxomil, an Angiotensin II Receptor Antagonist for the Treatment of Hypertension"],"prefix":"10.1111","volume":"121","author":[{"given":"Marie","family":"Hjermitslev","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Pharmacology Aarhus University Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela G.","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pharmacology Aarhus University Aarhus C Denmark"},{"name":"Clinic for Plastic, Aesthetic and Hand Surgery 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