{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:40:51Z","timestamp":1781649651430,"version":"3.54.5"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Technology R&D Program","award":["2013BAI09B04"],"award-info":[{"award-number":["2013BAI09B04"]}]},{"name":"National Basic Research Program of China 973","award":["2012CB517600"],"award-info":[{"award-number":["2012CB517600"]}]},{"name":"National Basic Research Program of China 973","award":["2012CB517606"],"award-info":[{"award-number":["2012CB517606"]}]},{"name":"Clinical Research Program of Jiangsu Province","award":["BL2012007"],"award-info":[{"award-number":["BL2012007"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Valproic acid (<jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>) is widely used for the treatment of epilepsy. However, its overdose can cause intoxication and could be life\u2010threatening. Due to the lack of specific antidote and poorness of endogenous clearance, extracorporeal treatment for severe intoxication cases is indicated. Here, we report a case of severe intoxication of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> which was successfully treated with liver support therapy. A previously healthy woman was admitted due to coma and hypotension after intentional ingestion of 20 g of sodium valproate. Her serum concentration of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> measured on admission was 420.84 mg\/L. In addition to standard therapy, she received two sessions of extracorporeal blood purification using a system based on fractionated plasma separation and adsorption mode integrated with continuous veno\u2010venous haemofiltration (<jats:styled-content style=\"fixed-case\">FPSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CVVH<\/jats:styled-content>), which is usually used for liver support therapy at our hospital. Her serum concentration of <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> decreased dramatically to 40.18 mg\/L and her consciousness recovered completely within 24 hr after admission. Therefore, although haemodialysis has been reported to be effective in the treatment for <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> poisoning, <jats:styled-content style=\"fixed-case\">FPSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CVVH<\/jats:styled-content> may provide an option for patients who require bedside therapy but have an unstable haemodynamic status or other conditions that result in inability to endure haemodialysis.<\/jats:p>","DOI":"10.1111\/bcpt.12807","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T15:36:41Z","timestamp":1494257801000},"page":"368-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy"],"prefix":"10.1111","volume":"121","author":[{"given":"Yongchun","family":"Ge","sequence":"first","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunpeng","family":"He","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehua","family":"Gong","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.987397"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1035441"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70235-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19387"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.462"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342111"},{"issue":"3","key":"e_1_2_6_8_1","first-page":"173","article-title":"Continuous veno\u2010venous haemodiafiltration in sodium valproate overdose complicated by cerebral oedema: a case report","volume":"4","author":"Field J","year":"2002","journal-title":"Crit Care Resusc"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:15:52Z","timestamp":1695546952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/bcpt.12807"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12807","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,27]]},"assertion":[{"value":"2017-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}