{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:58:43Z","timestamp":1771034323203,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate clinical manifestations, age distribution and risk factors of adverse drug reactions (<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s) of statins. Korean Adverse Event Reporting System (<jats:styled-content style=\"fixed-case\">KAERS<\/jats:styled-content>) database records (July 2009\u2013June 2014) on statin\u2010treated adults were used. <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s classified as \u2018certain\u2019, \u2018probable\u2019 and \u2018possible\u2019 based on the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\u2010Uppsala Monitoring Centre criteria were analysed. The frequency of <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s was compared between adults (18\u201364 years) and older people (age \u226565 years) groups. In total, 2161 <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s from 1690 patients (579, 34.3% older people) were included for analysis. Mean patient age and <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s per patient were 60.46 \u00b1 12.72 years and 1.28, respectively. <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s were reported with atorvastatin (48.4%), rosuvastatin (23.0%), pitavastatin (10.4%) and simvastatin (9.1%). The frequent <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s were gastrointestinal (421 events, 19.5%), musculoskeletal (331, 15.3%), skin (312, 14.4%) and hepatobiliary disorders (286, 13.2%). Skin disorders were significantly more frequent in adults compared to those in older patients (16.3% <jats:italic>versus<\/jats:italic> 12.4%, <jats:italic>p<\/jats:italic> = 0.021). Common clinical symptoms were myalgia (263 events, 12.2%), dyspepsia (133, 6.2%) and pruritus (103, 4.8%). Myalgia was more frequently reported in adults (12.7% <jats:italic>versus<\/jats:italic> 9.5%, <jats:italic>p<\/jats:italic> = 0.039) and dizziness was more frequent in older people (3.4% <jats:italic>versus<\/jats:italic> 5.8%, <jats:italic>p<\/jats:italic> = 0.015). According to <jats:styled-content style=\"fixed-case\">KAERS<\/jats:styled-content> data, leading statin <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s were gastrointestinal and musculoskeletal disorders. Myalgia and dyspepsia were the common clinical symptoms.<\/jats:p>","DOI":"10.1111\/bcpt.12808","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T14:46:39Z","timestamp":1494686799000},"page":"409-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of National Pharmacovigilance Data Associated with Statin Use in Korea"],"prefix":"10.1111","volume":"121","author":[{"given":"Hyunah","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy Sookmyung Women's University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namhyo","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Sookmyung Women's University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hun\u2010Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2015.02.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.11.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179564"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199732050-00005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-010-0143-2"},{"key":"e_1_2_7_8_1","unstructured":"Lexicomp Online. [online database].http:\/\/online.lexi.com. (last accessed 25 October 2016)."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/12.1.69"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2.5.447"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C126"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/15748863113089990030"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2004.010611"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1076-7460.2002.01422.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0000000000000024"},{"key":"e_1_2_7_16_1","first-page":"64","article-title":"Liver injury incidence and risk after statin use","volume":"3","author":"Kim Y","year":"2010","journal-title":"JPERM"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3715"},{"key":"e_1_2_7_18_1","unstructured":"World Health Organization Website.WHO\u2010UMC causality assessment. [Internet].http:\/\/www.who-umc.org. (last accessed 25 October 2016)."},{"key":"e_1_2_7_19_1","unstructured":"World Health Organization Website.The WHO Adverse Reaction Terminology (WHO\u2010ART). [Internet].http:\/\/www.umc-products.com. (last accessed 25 October 2016)."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02799-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689108400612"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-100"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028124"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.625"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.08.020"},{"key":"e_1_2_7_26_1","first-page":"1","article-title":"Prescription cholesterol\u2010lowering medication use in adults aged 40 and over: United States, 2003\u20132012","volume":"177","author":"Gu Q","year":"2014","journal-title":"NCHS Data Brief"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1430"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4065\/79.1.122"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39520.671053.94"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132916"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1287"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-009-0002-1"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60897-5"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00005"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1116"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/13651500903434461"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2569"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.11.026"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.5.459"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f880"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:47:12Z","timestamp":1695991632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/bcpt.12808"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12808","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]},"assertion":[{"value":"2017-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}