{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:55:04Z","timestamp":1777517704168,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["10\u2010092792\/DSF"],"award-info":[{"award-number":["10\u2010092792\/DSF"]}],"id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the influence of variations in the carboxylesterase 1 gene (<jats:italic>CES1)<\/jats:italic>on the pharmacokinetics of enalapril. Forty\u2010three healthy, Danish, Caucasian volunteers representing different pre\u2010defined genotypes each received 10 mg of enalapril. At specified time\u2010points, plasma concentrations of enalapril and the active metabolite enalaprilat were measured. The volunteers were divided into six different groups according to their genetic profile of<jats:italic>CES1<\/jats:italic>: group 1 (control group, n = 16) with two<jats:italic>CES1<\/jats:italic>copies without non\u2010synonymous SNPs in the exons; group 2 (n = 5) with four copies of<jats:italic>CES1<\/jats:italic>; group 3 (n = 6) harbouring the G143E polymorphism; group 4 (n = 2) with three<jats:italic>CES1<\/jats:italic>copies and increased transcriptional activity of the duplication (<jats:italic>CES1A2<\/jats:italic>); group 5 (n = 4) harbouring the<jats:italic>CES1A1c<\/jats:italic>variant; and group 6 (n = 10) with three<jats:italic>CES1<\/jats:italic>copies and the common promoter with low transcriptional activity of the duplication. The median AUC of enalaprilat in the control group was not significantly different from any of the other five groups (297 ng\/ml x h in the control group<jats:italic>versus<\/jats:italic>310, 282, 294, 344 and 306 ng\/ml x h in groups 2\u20136, respectively). The terminal half\u2010life of enalaprilat was significantly longer in group 6 compared with the control group (26.7 hr<jats:italic>versus<\/jats:italic>12.7 hr, respectively). However, this was not considered clinically relevant. In conclusion, none of the selected variations of<jats:italic>CES1<\/jats:italic>had a clinically relevant impact on the metabolism of enalapril.<\/jats:p>","DOI":"10.1111\/bcpt.12835","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:34:45Z","timestamp":1498091685000},"page":"487-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Pharmacokinetics of Enalapril in Relation to<i>CES1<\/i>Genotype in Healthy Danish Volunteers"],"prefix":"10.1111","volume":"121","author":[{"given":"Claus","family":"Stage","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg University Hospital Copenhagen NV Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gesche","family":"J\u00fcrgens","sequence":"additional","affiliation":[{"name":"Clinical Pharmacological Unit Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise Schow","family":"Guski","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg University Hospital Copenhagen NV Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragnar","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte","family":"Bjerre","sequence":"additional","affiliation":[{"name":"Institute of Biological Psychiatry Mental Health Centre Sct. Hans Copenhagen University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ferrero\u2010Miliani","sequence":"additional","affiliation":[{"name":"Institute of Biological Psychiatry Mental Health Centre Sct. Hans Copenhagen University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassine Kamal","family":"Lyauk","sequence":"additional","affiliation":[{"name":"Clinical Pharmacological Unit Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik Berg","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Institute of Biological Psychiatry Mental Health Centre Sct. Hans Copenhagen University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Dalhoff","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg University Hospital Copenhagen NV Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The INDICES Consortium (for members of this consortium\u2010see Supplementum)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60235-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.053512"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13020412"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32830b0c5e"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000230110.18957.50"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000206"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1315-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.42"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.120"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.04.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.13"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12667"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03695.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13237"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bks065"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.20.869"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.12.017"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001494"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-3565(25)30016-9","article-title":"Metabolism and disposition of methylphenidate\u201014C: studies in man and animals","volume":"191","author":"Faraj BA","year":"1974","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1982.tb01991.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018956526016"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1986.tb05205.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.04.018"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T22:18:21Z","timestamp":1750371501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/bcpt.12835"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12835","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]},"assertion":[{"value":"2017-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}