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The aim of our study was to explore whether pharmacotherapy for concurrent diseases affects overall mortality, liver\u2010related mortality and liver\u2010related morbidity in patients with chronic liver disease. We performed a register\u2010based cohort study of all patients with a first\u2010time diagnosis of chronic liver disease between 2005 and 2012 in Sweden (n\u00a0=\u00a070\u00a0546). Data from the Patient Register, the Prescribed Drug Register and the Death Certificate Register were linked<jats:bold>.<\/jats:bold> We studied whether the use of statins, angiotensin\u2010converting enzyme inhibitors, angiotensin receptor blockers and antibiotics affected the risk of total mortality, liver\u2010specific mortality and morbidity. We found a reduction in mortality risk for statin users (n\u00a0=\u00a011,245) with hazard ratios from 0.57 (95% CI: 0.32\u20130.99) for patients with autoimmune hepatitis to 0.84 (95% CI: 0.75\u20130.95) for patients with alcoholic liver disease. There was a significantly reduced liver\u2010related mortality for patients with alcoholic liver disease who used angiotensin\u2010converting enzyme inhibitors, 0.85 (95% CI: 0.65\u20130.96). There were increased overall mortality risks for antibiotic users (n\u00a0=\u00a044,572), with hazard ratios up to 1.67 (95% CI, 1.55\u20131.80) for viral hepatitis. Statin use was associated with decreased risks of liver\u2010specific mortality and morbidity, and reduced total mortality foremost among patients with alcoholic liver disease. Angiotensin \u2010converting enzyme inhibitors was associated with reduced liver\u2010related mortality among patients with alcoholic liver disease.<\/jats:p>","DOI":"10.1111\/bcpt.12844","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T08:12:48Z","timestamp":1499674368000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Statins and Angiotensin\u2010Converting Enzyme Inhibitors are Associated with Reduced Mortality and Morbidity in Chronic Liver Disease"],"prefix":"10.1111","volume":"122","author":[{"given":"Knut","family":"Stokkeland","sequence":"first","affiliation":[{"name":"Department of Medicine Visby Hospital Visby Sweden"},{"name":"Department of Medicine Huddinge Unit of Gastroenterology and Rheumatology Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine 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