{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:17:01Z","timestamp":1782775021766,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001063","name":"Crohn's and Colitis Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Information on the safety of paternal use of medications prior to the time of conception is limited, and there is little available evidence regarding possible adverse effects of <jats:italic>paternal<\/jats:italic> use of systemic corticosteroids (<jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>). In this cohort study, based on nationwide data, we examined the association between paternal use of <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> prior to conception and adverse birth outcome. The study includes data from all singletons born in Denmark from 1 January 1997 through 2013 (N = 1,013,994). Children fathered by men who redeemed a prescription of <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> within 3 months before conception (N = 2380) constituted the exposed groups. The outcome was congenital abnormalities (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>s), pre\u2010term birth and small\u2010for\u2010gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>). We adjusted for co\u2010variates in multi\u2010level logistic regression analyses. The adjusted odds ratios for pre\u2010term birth and <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> were 0.81 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.55\u20131.21) and 1.06 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.68\u20131.64), respectively. The adjusted odds ratios for <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>s were 1.08 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.87\u20131.40) in children fathered by men who redeemed one prescription within 3 months before conception and 1.33 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.99\u20131.79) in children fathered by men who redeemed two or more prescriptions. This study is the largest to date examining the effect of paternal use of <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> prior to conception on birth outcome. We found no significantly increased risk of pre\u2010term birth or <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>. In children of fathers who redeemed at least two prescriptions of <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> within 3 months before conception, we found an increased risk of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>s, though not statistically significant. The types of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>s did not show a distinct pattern.<\/jats:p>","DOI":"10.1111\/bcpt.12857","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T08:43:08Z","timestamp":1502700188000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Birth Outcome of Children Fathered by Men Treated with Systemic Corticosteroids during the Conception Period \u2013 A Cohort Study based on Nationwide Data"],"prefix":"10.1111","volume":"122","author":[{"given":"Michael Due","family":"Larsen","sequence":"first","affiliation":[{"name":"Center for Clinical Epidemiology Odense University Hospital Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Friedman","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology Odense University Hospital Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology University of Southern Denmark Odense Denmark"},{"name":"Center for Crohn's and Colitis Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne","family":"Magnussen","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology Odense University Hospital Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente Mertz","family":"N\u00f8rg\u00e5rd","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology Odense University Hospital Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology University of Southern Denmark Odense Denmark"},{"name":"Center for Crohn's and Colitis Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"3","article-title":"Effects of pharmaceutical medications on male fertility","volume":"13","author":"Brezina PR","year":"2012","journal-title":"J Reprod Infertil"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04426.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001081"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90292-7"},{"key":"e_1_2_9_6_1","first-page":"577","article-title":"Effect of methotrexate on male fertility","volume":"49","author":"French AE","year":"2003","journal-title":"Can Fam 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