{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T11:16:45Z","timestamp":1794395805870,"version":"4.9.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vancomycin is a glycopeptide antibiotic used to treat Gram\u2010positive infections including methicillin\u2010resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content>). The objectives of this study were to evaluate the appropriateness of the initial dosing regimen of vancomycin, identify factors to be considered in regimen selection and develop a new dosing nomogram. Therapeutic drug monitoring (<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>) data of vancomycin obtained from Seoul National University Hospital from 2011 to 2013 were included in this analysis. The vancomycin trough concentrations at steady\u2010state were estimated using Abbott's<jats:styled-content style=\"fixed-case\">PKS<\/jats:styled-content>software program and then categorized into three levels: subtherapeutic, therapeutic and toxic. The newly developed nomograms were evaluated by analysing the percentage of patients with target vancomycin trough concentration using the data of 2,570 patients of the first<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>cases. Therapeutic level was achieved only in approximately one\u2010fifth of the cases, while 56.0% and 23.8% of the<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>s were considered subtherapeutic and toxic, respectively. As body\u2010weight and creatinine clearance (Cr<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>) increased, the proportion of patients with a subtherapeutic level increased. Using the newly developed nomogram increased the proportion of patients who achieved therapeutic levels from 23.1% to 45.0% or 13.8% to 36.2% (target, 10\u201315 and 15\u201320 mg\/L, respectively). These results suggest that the vancomycin concentrations fail to reach the therapeutic level or exceed the safe upper margin of the therapeutic level depending on age, body\u2010weight and Cr<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>. Considering these factors, the new nomograms provide a strategy to achieve target concentrations of vancomycin more rapidly than existing regimens.<\/jats:p>","DOI":"10.1111\/bcpt.12873","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T09:16:38Z","timestamp":1503220598000},"page":"233-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Assessment of Appropriateness of an Initial Dosing Regimen of Vancomycin and Development of a New Dosing Nomogram"],"prefix":"10.1111","volume":"122","author":[{"given":"Seonghae","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Ryun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SeungHwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Beom","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Sang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3947\/ic.2012.44.6.411","article-title":"The changing patterns of antibiotics usage in Korea during 1981\u20102008","volume":"44","author":"Kim YJ","year":"2012","journal-title":"Infect Chemother"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-002-0215-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1067\/mic.2000.107592","article-title":"Multicenter surveillance study for nosocomial infections in major hospitals in Korea. 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