{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:07:08Z","timestamp":1781125628251,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The last eight survivors of 80 workers accidentally exposed to 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin (<jats:styled-content style=\"fixed-case\">TCDD<\/jats:styled-content>) during production of herbicides based on trichlorophenoxyacetic acid in 1965\u20131967 in a chemical factory were followed. All were men, mean age 72.4 \u00b1 1.3 years. Their current median <jats:styled-content style=\"fixed-case\">TCDD<\/jats:styled-content> blood level was 112 (46\u2013390) pg\/g lipids. Neurological examination revealed central nervous system impairment in all individuals and signs of polyneuropathy in 87.5%, which was confirmed by a nerve conduction study (<jats:styled-content style=\"fixed-case\">NCS<\/jats:styled-content>) in 75%. A Lanthony test demonstrated acquired dyschromatopsia in 87.5% of the patients, with deterioration of mean colour confusion index (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>) from 1.52 \u00b1 0.39 in 2010 to 1.73 \u00b1 0.41 in 2016. Single\u2010photon emission computer tomography (<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>) of the brain showed focal reduction of perfusion in various brain locations in all patients and worsening in six patients. Visual\u2010evoked potentials (<jats:styled-content style=\"fixed-case\">VEP<\/jats:styled-content>) was abnormal in 62.6% of individuals. Most patients complained of psychological problems. The neuropsychological test battery showed most positive impairments in the Trail Making Test evaluating processing speed (average level in the range of mild neurocognitive impairment), which correlated with mean <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> (<jats:italic>p<\/jats:italic> &lt; 0.05). Conclusion: Fifty years after exposure, blood levels of <jats:styled-content style=\"fixed-case\">TCDD<\/jats:styled-content> are still 10 times higher than the general population. <jats:styled-content style=\"fixed-case\">NCS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VEP<\/jats:styled-content>, Lanthony test and <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content> findings deteriorated from examination of these patients in 2004 and in 2010. The total of abnormal tests per patient in 2016 is very high. Minor differences among patients and their reduced count may explain why the number of impairments in 2016 does not correlate with <jats:styled-content style=\"fixed-case\">TCDD<\/jats:styled-content> blood level.<\/jats:p>","DOI":"10.1111\/bcpt.12899","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T14:12:39Z","timestamp":1504275159000},"page":"271-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neurological and Neurophysiological Findings in Workers with Chronic 2,3,7,8\u2010Tetrachlorodibenzo\u2010<i>p<\/i>\u2010Dioxin Intoxication 50 Years After Exposure"],"prefix":"10.1111","volume":"122","author":[{"given":"Daniela","family":"Pelclova","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"},{"name":"National Institute of Public Health Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenka","family":"Fenclova","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepanka","family":"Vlckova","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Ridzon","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Kupka","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Meckova","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Bezdicek","sequence":"additional","affiliation":[{"name":"Department of Neurology First Faculty of Medicine Charles University and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Navratil","sequence":"additional","affiliation":[{"name":"J. 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