{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T22:29:18Z","timestamp":1771799358156,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to characterize the clinical signs and symptoms of exposures to aripiprazole overdoses. We retrospectively identified all aripiprazole exposures reported to the Danish Poison Information Centre (<jats:styled-content style=\"fixed-case\">DPIC<\/jats:styled-content>) from June 2007 to May 2015. Information concerning demographics, ingested dose and symptoms was extracted from the <jats:styled-content style=\"fixed-case\">DPIC<\/jats:styled-content> database and medical records. Information on death and admission to hospital was obtained from Danish national registers. We analysed 239 cases, 86 concerning single\u2010drug exposures to aripiprazole, and 153 cases where aripiprazole had been taken with at least one other substance (mixed\u2010drug). The median ingested aripiprazole dose was 105 mg (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 50\u20101680 mg) in the single\u2010drug exposure group and 120 mg (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 60\u2010225 mg) in the mixed\u2010drug exposure group<jats:bold>.<\/jats:bold> The most commonly reported symptom was light sedation, reported in 63% of the single\u2010drug group and 50% of the mixed\u2010drug exposure group. There were no malignant arrhythmias or <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> abnormalities after single\u2010drug exposures. No deaths were recorded in relation to the intake. We found a long\u2010term mortality rate of 13 deaths per 1000 person\u2010years (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 7; 23 per 1000 person\u2010years), which is significantly higher than in an age\u2010 and gender\u2010matched background population. In conclusion, we found that aripiprazole overdoses had few and mild symptoms predominantly related to the sedative properties. We detected a benign cardiovascular safety profile and no new safety concerns. Our findings may support an increased threshold of 300 mg for hospital admission after a single\u2010drug exposure with aripiprazole and symptoms not worse than light sedation.<\/jats:p>","DOI":"10.1111\/bcpt.12902","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T18:55:54Z","timestamp":1504810554000},"page":"293-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Overdoses with Aripiprazole: Signs, Symptoms and Outcome in 239 Exposures Reported to the Danish Poison Information Centre"],"prefix":"10.1111","volume":"122","author":[{"given":"Amalie P.","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soeren","family":"Boegevig","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel B.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper M.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim P.","family":"Dalhoff","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonny S.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90066-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.107"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2014.12.005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(03)00600-0"},{"key":"e_1_2_6_6_1","unstructured":"Top 100 Most Prescribed Top\u2010Selling Drugs [Internet]. 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