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The numerous investigations on <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>s and their use in nanomedicine have received considerable attention in the last three decades, leading to the rapid development of new <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\u2010containing formulations that significantly facilitate targeted drug delivery and controlled drug release, with consequent improvements in drug bioavailability. This MiniReview highlights the efficacy and recent uses of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>s for non\u2010invasive drug delivery. Using ophthalmic and nasal drug delivery as examples, an overview of chemical properties, mechanisms of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>s on drug solubilization, stabilization and permeation, along with their toxicological profiles relevant to nasal and ocular administration, are provided and discussed. 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