{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:03:32Z","timestamp":1781021012391,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methadone has a long history of pain relief and successful substitute for maintenance treatment in heroin and narcotic addiction. The aim of the study was to assess the trends of methadone\u2010associated deaths in Tehran, Iran, in 2009\u20132015, from a forensic toxicology point of view. All methadone\u2010associated deaths during this 7\u2010year study period were evaluated according to demographic parameters and forensic toxicology analysis results. Results showed that 1274 cases of methadone\u2010associated deaths were investigated during the study period. The incidence rate of methadone\u2010associated deaths had risen 7.7 times in 2015 in comparison with 2009 (<jats:italic>p<\/jats:italic> &lt; 0.05). The majority of cases were men (90.35%), aged from 20 to 40 years. About 80% of cases had shown positive results for other drugs and poisons in combination with methadone. Methamphetamine and tramadol were the most drugs detected in post\u2010mortem samples. Death rates among methadone users in Tehran, Iran, increased year by year during 2009\u20132015. These findings raise the attention to the concomitant use of drugs with the need for changes in regulation and regulatory policy to restrict access and use of controlled drugs.<\/jats:p>","DOI":"10.1111\/bcpt.12930","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T12:28:40Z","timestamp":1509107320000},"page":"436-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Forensic Toxicology Perspectives of Methadone\u2010associated Deaths in Tehran, Iran, a 7\u2010year Overview"],"prefix":"10.1111","volume":"122","author":[{"given":"Maryam","family":"Akhgari","sequence":"first","affiliation":[{"name":"Legal Medicine Research Center Legal Medicine Organization Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushin","family":"Amini\u2010Shirazi","sequence":"additional","affiliation":[{"name":"Legal Medicine Research Center Legal Medicine Organization Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba Sardari","family":"Iravani","sequence":"additional","affiliation":[{"name":"Legal Medicine Research Center Legal Medicine Organization Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.09.021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2017.04.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.15171\/ijhpm.2015.60"},{"key":"e_1_2_9_5_1","unstructured":"Guidelines for the psychosocially assisted pharmacological treatment of opioid dependence. 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