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Fourteen female Danish Landrace pigs (mean weight 27.7 kg, range 20\u201335 kg (CAC\u2010HP) and 24.4 kg, range 18\u201330 kg (control group, CG), n = 7 in each group) were included. After randomization, the pigs were anaesthetized and intravenously poisoned with AT. The intervention group underwent 4 hr of CAC\u2010HP plus standard care (oral activated charcoal). Intervention was compared to standard care alone. From each pig, a 12\u2010lead ECG and haemodynamic variables were obtained at baseline, at full AT loading dose, before and during CAC\u2010HP. Baseline ECG variables (RR, PR, QRS, QTc, QTp, QTe, TpTe and TpTe\/QT) for lead II, v2 and v5 were not significantly different (<jats:italic>F<\/jats:italic> = 0.035\u20130.297, <jats:italic>p<\/jats:italic>\u2010values 0.421\u20130.919). Differences within groups over time and between groups were tested by <jats:sc>anova<\/jats:sc> repeated measures. For all variables, the time\u2010plus\u2010group level of significance revealed a <jats:italic>p<\/jats:italic>\u2010value &gt; 0.05. Severe cardiovascular arrhythmias occurred in both groups with 3 in the CAC\u2010HP group <jats:italic>versus<\/jats:italic> 1 incident with premature death in the CG. The attenuating effect of CAC\u2010HP to orally instilled activated charcoal alone on AT\u2010induced ECG alterations did not differ significantly. We conclude that the use of modern CAC\u2010HP as an adjunctive treatment modality in AT\u2010poisoned pigs is inadequate.<\/jats:p>","DOI":"10.1111\/bcpt.12931","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T23:56:35Z","timestamp":1510185395000},"page":"442-447","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advanced Electrocardiogram Analysis in the Amitriptyline\u2010poisoned Pig Treated with Activated Charcoal Haemoperfusion"],"prefix":"10.1111","volume":"122","author":[{"given":"Tejs","family":"Jansen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital Bispebjerg Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte C. 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