{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:25:34Z","timestamp":1791977134074,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["114S927"],"award-info":[{"award-number":["114S927"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Amanita phalloides<\/jats:italic> species mushrooms containing alpha\u2010amanitin (\u03b1\u2010AMA<\/jats:styled-content>) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity and acute hepatic failure. Existing antidotes, such as silibinin, are not sufficiently effective in the prevention and\/or resolution of \u03b1\u2010AMA<\/jats:styled-content>\u2010induced hepatotoxicity. We investigated the effects of resveratrol on \u03b1\u2010AMA<\/jats:styled-content>\u2010induced hepatotoxicity and compared with silibinin, a known antidote using in vivo<\/jats:italic> and in vitro<\/jats:italic> toxicity models. In the in vivo<\/jats:italic> protocol, resveratrol (30 mg\/kg) was given simultaneously with \u03b1\u2010AMA<\/jats:styled-content> (\u03b1\u2010AMA<\/jats:styled-content> + SR<\/jats:styled-content>) or 12 (\u03b1\u2010AMA<\/jats:styled-content> + 12R) or 24 (\u03b1\u2010AMA<\/jats:styled-content> + 24R) hr after \u03b1\u2010AMA<\/jats:styled-content> administration. Silibinin (5 mg\/kg) (\u03b1\u2010AMA<\/jats:styled-content> + Sil) and normal saline (\u03b1\u2010AMA<\/jats:styled-content> + NS<\/jats:styled-content>) were given simultaneously with \u03b1\u2010AMA<\/jats:styled-content>. We found that liver transaminase levels in \u03b1\u2010AMA<\/jats:styled-content> + SR<\/jats:styled-content> and \u03b1\u2010AMA<\/jats:styled-content> + 12R groups and histomorphologic injury score in the \u03b1\u2010AMA<\/jats:styled-content> + SR<\/jats:styled-content>, \u03b1\u2010AMA<\/jats:styled-content> + 12R, \u03b1\u2010AMA<\/jats:styled-content> + 24R and \u03b1\u2010AMA<\/jats:styled-content> + Sil groups were significantly lower than that of the \u03b1\u2010AMA<\/jats:styled-content> + NS<\/jats:styled-content> group. Resveratrol decreased mononuclear cell infiltration, necrosis and active caspase\u20103 immunopositivity in the liver. In the in vitro<\/jats:italic> protocol, the effects of resveratrol and silibinin were evaluated in a reduction in cell viability induced by \u03b1\u2010AMA<\/jats:styled-content> in THLE<\/jats:styled-content>\u20102 and THLE<\/jats:styled-content>\u20103 hepatocytes. Neither resveratrol nor silibinin was found to be effective in increasing cell viability decreased by \u03b1\u2010AMA<\/jats:styled-content> + NS<\/jats:styled-content>. As a conclusion, resveratrol was found to be effective in \u03b1\u2010AMA<\/jats:styled-content>\u2010induced hepatotoxicity with its anti\u2010inflammatory properties in in vivo<\/jats:italic> conditions. It is a promising compound with the potential for use in the treatment of hepatotoxicity associated with Amanita phalloides<\/jats:italic> type mushroom poisonings.<\/jats:p>","DOI":"10.1111\/bcpt.12954","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T07:36:47Z","timestamp":1514533007000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha\u2010Amanitin\u2010Induced Hepatotoxicity"],"prefix":"10.1111","volume":"122","author":[{"given":"Aynur","family":"Sahin","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Karadeniz Technical University School of Medicine Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mualla Aylin","family":"Arici","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology Dokuz 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