{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:42:00Z","timestamp":1773020520392,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:00:00Z","timestamp":1523750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010term anti\u2010epileptic drug (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>) therapy compromises bone health. Although vitamin D deficiency is proposed to be involved, it alone is not held responsible. This accounts for investigating other mechanisms in bone accrual. Recent studies have shown modulation of inhibitors of wnt pathway, sclerostin and dickkopf\u20101 (<jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\u20101), in glucocorticoids\u2010induced osteoporosis. We investigated whether <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> monotherapy modulates wnt inhibitors in Indian women with epilepsy. Women of age &gt; 20\u201340 years with the diagnosis of epilepsy and receiving <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s (carbamazepine, valproate and levetiracetam) for at least a year were enrolled. The results were compared with age\u2010matched healthy controls with no evidence of metabolic bone disease. Women undergoing treatment with <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s (mean duration: 50.59 \u00b1 37.929 months) exhibited higher serum sclerostin and receptor activator of nuclear factor \u03ba B ligand (<jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>) and lower vitamin D (25\u2010hydroxy vitamin D) and <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\u20101 levels when compared to age\u2010matched healthy controls. Sclerostin showed a positive correlation with <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>, while <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\u20101 presented no such relationship. However, no association was evident after adjusting for age, duration of treatment and total daily dose. Although a correlation between wnt inhibitors and <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> could not be obtained, <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s displayed changes in serum levels of wnt inhibitors in persons with epilepsy and hence these drugs may compromise bone health through a disturbance in wnt signalling mechanisms.<\/jats:p>","DOI":"10.1111\/bcpt.12996","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T12:22:54Z","timestamp":1520252574000},"page":"271-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Cross\u2010Sectional Study to Assess the Modulation of Wnt Inhibitors following Anti\u2010Epileptic Drug Therapy and their Correlation with Vitamin D and Receptor Activator of Nuclear Factor \u03ba B Ligand in Indian Women with Epilepsy"],"prefix":"10.1111","volume":"123","author":[{"given":"Bushra","family":"Parveen","sequence":"first","affiliation":[{"name":"Pharmaceutical Medicine Department of Pharmacology School of Pharmaceutical Education and Research Jamia Hamdard New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurosciences Centre All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Vohora","sequence":"additional","affiliation":[{"name":"Pharmaceutical Medicine Department of Pharmacology School of Pharmaceutical Education and Research Jamia Hamdard New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2007.08.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0185-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.23804.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.047"},{"key":"e_1_2_7_6_1","unstructured":"KanisJA.WHO Technical Report 2007.University of Sheffield UK;66."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2009.01.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152711794653797"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-3-36"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2006.11.007"},{"key":"e_1_2_7_11_1","first-page":"37","article-title":"Long\u2010term anticonvulsant therapy leads to low bone mineral density\u2010evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast\u2010like cells","volume":"108","author":"Feldkamp J","year":"2000","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.09.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.13002.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1983.tb04854.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00571-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.154"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1675-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1525-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2012.07.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.08.016"},{"key":"e_1_2_7_21_1","unstructured":"MonsD OostlanderA EssenH HeijboerA BodegravenA LipsPet al.Sclerostin and dickkopf1 (DKK1) expression in bone in relation to bone metabolism. 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