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Retinoblastoma protein\u2010interacting zinc finger gene 1 (\n                    <jats:styled-content style=\"fixed-case\">RIZ<\/jats:styled-content>\n                    1) has been suggested as a tumour suppressor gene, whereas its role in cervical cancer with or without radiotherapy has been unclear. In this study, two cervical cancer cell lines, HeLa and SiHa cells, stably transfected with\n                    <jats:styled-content style=\"fixed-case\">RIZ<\/jats:styled-content>\n                    1 overexpression plasmid were subjected to ionizing radiation, and their survival fractions were calculated by assessing their clonogenic abilities. Our results showed that the forced overexpression of\n                    <jats:styled-content style=\"fixed-case\">RIZ<\/jats:styled-content>\n                    1 significantly reduced the clonogenic survival rates of both HeLa and SiHa cells exposed to ionizing radiation. By analysing the cell apoptotic status, we found that the\n                    <jats:styled-content style=\"fixed-case\">RIZ<\/jats:styled-content>\n                    1\u2010overexpressed cervical cancer cells under ionizing radiation were more vulnerable to damage, and more \u03b3\u2010H2\n                    <jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content>\n                    foci were found in these cells. Furthermore, the volumes of tumour xenografts formed by the\n                    <jats:styled-content style=\"fixed-case\">RIZ<\/jats:styled-content>\n                    1\u2010overexpressed cells in nude mice under ionizing radiation were smaller than those generated by the control cells. There were more morphological changes, apoptosis cells and lower expression of\n                    <jats:styled-content style=\"fixed-case\">PCNA<\/jats:styled-content>\n                    in\n                    <jats:styled-content style=\"fixed-case\">RIZ<\/jats:styled-content>\n                    1\u2010overexpressed tumour tissues of mice after exposure to ionizing radiation. Taken together, our study demonstrates that the overexpression of\n                    <jats:styled-content style=\"fixed-case\">RIZ<\/jats:styled-content>\n                    1 combined with radiotherapy facilitates apoptosis and\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    damage of cervical cancer cells.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.13008","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:58:33Z","timestamp":1521986313000},"page":"137-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Combination of\n                    <scp>RIZ<\/scp>\n                    1 Overexpression and Radiotherapy Contributes to Apoptosis and\n                    <scp>DNA<\/scp>\n                    Damage of HeLa and SiHa Cervical Cancer 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