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There is large inter\u2010individual variability in its pharmacokinetics. Single nucleotide polymorphisms (SNPs) in genes encoding TAC metabolizing enzymes cytochromes P450 3A4\/5 (<jats:italic>CYP3A4\/5<\/jats:italic>), P\u2010glycoprotein efflux transporter (<jats:italic>ABCB1<\/jats:italic>), their expression regulator pregnane X receptor (<jats:italic>NR1I2<\/jats:italic>) and CYP3A co\u2010factor cytochrome P450 reductase (<jats:italic>POR<\/jats:italic>) have been studied for their effects on tacrolimus disposition. However, except for<jats:italic>CYP3A5*3<\/jats:italic>, controversies remain about their roles in predicting dose\u2010adjusted trough blood TAC concentrations (C<jats:sub>0<\/jats:sub>\/D). This study aimed to investigate the effects of<jats:italic>ABCB1<\/jats:italic>(61A&gt;G, 1199G&gt;A, 1236C&gt;T, 2677G&gt;T and 3435C&gt;T),<jats:italic>CYP3A4*22<\/jats:italic>,<jats:italic>CYP3A5*3<\/jats:italic>,<jats:italic>NR1I2<\/jats:italic>(8055C&gt;T, 63396C&gt;T and \u201025385C&gt;T) and<jats:italic>POR*28<\/jats:italic>SNPs on TAC C<jats:sub>0<\/jats:sub>\/D. In total, 165 kidney transplant recipients were included in this study. SNPs were genotyped by probe\u2010based real\u2010time polymerase chain reaction. Associations between log\u2010transformed whole blood TAC C<jats:sub>0<\/jats:sub>\/D (measured at 1 and 3 months post\u2010transplant) and genotypes\/haplotypes were assessed by linear mixed effects analysis, controlling for age, sex and haematocrit. It was observed that<jats:italic>CYP3A5<\/jats:italic>expressors (<jats:italic>*1\/*1<\/jats:italic>+<jats:italic>*1\/*3<\/jats:italic>) (<jats:italic>p<\/jats:italic>= 5.5 \u00d7 10<jats:sup>\u221216<\/jats:sup>) and<jats:italic>ABCB1<\/jats:italic>61G allele carriers (<jats:italic>p<\/jats:italic>= 0.001) had lower log\u2010transformed TAC C<jats:sub>0<\/jats:sub>\/D (56% and 26% lower geometric mean TAC C<jats:sub>0<\/jats:sub>\/D, respectively) and accounted for approximately 30% and 4%, respectively, of log\u2010transformed TAC C<jats:sub>0<\/jats:sub>\/D variability in the first 3 months post\u2010transplant. In conclusion,<jats:italic>CYP3A5*3<\/jats:italic>is a major, and<jats:italic>ABCB1<\/jats:italic>61A&gt;G is a novel, although minor, genetic factor affecting TAC C<jats:sub>0<\/jats:sub>\/D in kidney transplant recipients.<\/jats:p>","DOI":"10.1111\/bcpt.13016","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T05:22:01Z","timestamp":1522473721000},"page":"320-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["<i>CYP3A5*3<\/i>and<i>ABCB1<\/i>61A&gt;G Significantly Influence Dose\u2010adjusted Trough Blood Tacrolimus Concentrations in the First Three Months Post\u2010Kidney Transplantation"],"prefix":"10.1111","volume":"123","author":[{"given":"Rong","family":"Hu","sequence":"first","affiliation":[{"name":"Discipline of Pharmacology Adelaide Medical School University of Adelaide Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel T.","family":"Barratt","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology Adelaide Medical School University of Adelaide Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet K.","family":"Coller","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology Adelaide Medical School University of Adelaide Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta C.","family":"Sallustio","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology Adelaide Medical School University of Adelaide Adelaide SA Australia"},{"name":"Department of Pharmacology Queen Elizabeth Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Somogyi","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology Adelaide Medical School University of Adelaide Adelaide SA Australia"},{"name":"Department of Clinical Pharmacology Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"ANZDATA Registry.39th Report Chapter 8: Transplantation. 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