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Murrayanine was reported to possess potential antioxidant, antimycobacterial and antifungal effects. However, its effect in sepsis remains unclear. This study was designed to investigate the anti\u2010inflammatory effect of<jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>using both<jats:italic>in\u00a0vitro<\/jats:italic>and<jats:italic>in\u00a0vivo<\/jats:italic>assay. Results of this study indicated that<jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>decreased<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 production in both lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>)\u2010stimulated<jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells and murine peritoneal macrophages. Moreover,<jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 protein expression as well as their downstream product,<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2, was also decreased effectively in<jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells. Furthermore,<jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>decreased the phosphorylation of<jats:styled-content style=\"fixed-case\">IKB<\/jats:styled-content>and repressed<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">kB<\/jats:styled-content>activity in<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010activated<jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells. Additionally, we evaluated<jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>efficacy<jats:italic>in\u00a0vivo<\/jats:italic>using<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced sepsis, a systemic inflammation model in mice. Administration of<jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>inhibits pro\u2010inflammatory cytokines (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) secretion; decreases<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">BUN<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CRE<\/jats:styled-content>level in mouse sera; mitigates lung, liver and kidney injuries; and also increases<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010challenged mice survival rate. Collectively, our results suggest that<jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>exerts potential as a new anti\u2010inflammatory and immunosuppressive drug in sepsis treatment.<\/jats:p>","DOI":"10.1111\/bcpt.13032","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T18:37:06Z","timestamp":1525286226000},"page":"351-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Murrayanine Attenuates Lipopolysaccharide\u2010induced Inflammation and Protects Mice from Sepsis\u2010associated Organ Failure"],"prefix":"10.1111","volume":"124","author":[{"given":"Shilpa","family":"Gupta","sequence":"first","affiliation":[{"name":"Academy of Scientific and Innovative Research CSIR\u2010Indian Institute of Integrative Medicines Jammu Tawi Jammu and Kashmir India"},{"name":"Inflammation Pharmacology Division CSIR\u2010Indian Institute of Integrative Medicines Jammu Tawi 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