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However, the biocompatibility of aHPG<\/jats:styled-content>\u2010basedPD<\/jats:styled-content>solution (HPG<\/jats:styled-content>) in subjects with MetS has not been investigated. This study compared the local and systemic effects of aHPG<\/jats:styled-content>solution with conventional physioneal (PYS<\/jats:styled-content>) and icodextrin (ICO<\/jats:styled-content>)PD<\/jats:styled-content>solutions in rats with MetS. Obese type 2 diabeticZSF<\/jats:styled-content>1 rats received a daily intraperitoneal injection ofPD<\/jats:styled-content>solutions (10\u00a0mL<\/jats:styled-content>) for 3\u00a0months. The peritoneal membrane (PM<\/jats:styled-content>) function was determined by ultrafiltration (UF<\/jats:styled-content>), and the systemic responses were determined by profiling blood metabolic substances, cytokines and oxidative status. Tissue damage was assessed by histology. At the end of the 3\u2010month treatment withPD<\/jats:styled-content>solutions,PM<\/jats:styled-content>damage andUF<\/jats:styled-content>loss in both thePYS<\/jats:styled-content>andICO<\/jats:styled-content>groups were greater than those in theHPG<\/jats:styled-content>group. Blood analyses showed that compared to the baseline control, the rats in theHPG<\/jats:styled-content>group exhibited a significant decrease only in serum albumin andIL<\/jats:styled-content>\u20106 and a minor glomerular injury, whereas in both thePYS<\/jats:styled-content>andICO<\/jats:styled-content>groups, there were more significant decreases in serum albumin, antioxidant activity,IL<\/jats:styled-content>\u20106,KC<\/jats:styled-content>\/GRO<\/jats:styled-content>(CXCL<\/jats:styled-content>1) andTNF<\/jats:styled-content>\u2010\u03b1 (inICO<\/jats:styled-content>only) as well as a more substantial glomerular injury compared to theHPG<\/jats:styled-content>group. Furthermore,PYS<\/jats:styled-content>increased serum creatinine, serum glucose and urine production. In conclusion, compared toPYS<\/jats:styled-content>orICO<\/jats:styled-content>solutions, theHPG<\/jats:styled-content>solution had less adverse effects locally on thePM<\/jats:styled-content>and systemically on distant organs (e.g. kidneys) and the plasma oxidative status in rats with MetS.<\/jats:p>","DOI":"10.1111\/bcpt.13038","type":"journal-article","created":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T23:00:31Z","timestamp":1526166031000},"page":"494-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peritoneal and Systemic Responses of Obese TypeII<\/scp>Diabetic Rats to Chronic Exposure to a Hyperbranched Polyglycerol\u2010Based Dialysis Solution"],"prefix":"10.1111","volume":"123","author":[{"given":"Bo","family":"La Han","sequence":"first","affiliation":[{"name":"Department of Urologic Sciences University of British Columbia Vancouver BC 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