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This MiniReview provides the reader with an overview of current and future treatment options for patients with <jats:styled-content style=\"fixed-case\">PPHN<\/jats:styled-content> without congenital diaphragmatic hernia. The study is based on systematic searches in the databases PubMed and Cochrane Library and registered studies on Clinicaltrials.gov investigating <jats:styled-content style=\"fixed-case\">PPHN<\/jats:styled-content>. Inhaled nitric oxide (<jats:styled-content style=\"fixed-case\">iNO<\/jats:styled-content>) is well documented for treatment of <jats:styled-content style=\"fixed-case\">PPHN<\/jats:styled-content>, but 30% fail to respond to <jats:styled-content style=\"fixed-case\">iNO<\/jats:styled-content>. Other current treatment options could be sildenafil, milrinone, prostaglandin analogues and bosentan. There are several ongoing trials with sildenafil, but evidence is lacking for the other treatments and\/or for the combination with <jats:styled-content style=\"fixed-case\">iNO<\/jats:styled-content>. Currently, there is no evidence for effect in <jats:styled-content style=\"fixed-case\">PPHN<\/jats:styled-content> of other treatments, for example tadalafil, macitentan, ambrisentan, riociguat and selexipag used for pulmonary arterial hypertension in adults. Experimental studies in animal models for <jats:styled-content style=\"fixed-case\">PPHN<\/jats:styled-content> suggest effect of a series of approaches including recombinant human superoxide dismutase, L\u2010citrulline, Rho\u2010kinase inhibitors and peroxisome proliferator\u2010activated receptor\u2010\u03b3 agonists. We conclude that <jats:styled-content style=\"fixed-case\">iNO<\/jats:styled-content> is the most investigated and the only approved pulmonary vasodilator for infants with <jats:styled-content style=\"fixed-case\">PPHN<\/jats:styled-content>. In the <jats:styled-content style=\"fixed-case\">iNO<\/jats:styled-content> non\u2010responders, sildenafil currently seems to be the best alternative either alone or in combination with <jats:styled-content style=\"fixed-case\">iNO<\/jats:styled-content>. Systematic and larger clinical studies are required for testing the other potential treatments of PPHN.<\/jats:p>","DOI":"10.1111\/bcpt.13051","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T07:53:57Z","timestamp":1527839637000},"page":"392-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn"],"prefix":"10.1111","volume":"123","author":[{"given":"Jonas","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Pharmacology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise R.","family":"Hedegaard","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pharmacology Aarhus University Aarhus 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