{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:50:26Z","timestamp":1777614626910,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapeutic drug monitoring (<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>) is used to determine the concentration of drug in plasma\/serum to adjust the dose of the therapeutic drug. Selective and sensitive analytical methods are used to determine drug and metabolite levels for the successful application of <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>. The aim of the study was to develop and validate using <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> to analyse quantitative assay of escitalopram (S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) and metabolites in human plasma samples. In order to provide a convenient and safe treatment dose, it was aimed to determine the levels of S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and its metabolites in the patients\u2019 plasma. A new method with short sample preparation and analysis time was developed and validated using <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> to analyse quantitative assay of S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and its metabolites in plasma. Also, plasma samples of 30 patients using 20\u00a0mg S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> between the ages of 18 and 65\u00a0years were analysed by the validated method. The mean values of S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, demethyl escitalopram and didemethyl escitalopram in plasma of patients were 27.59, 85.52 and 44.30\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively. At the end of the analysis, the metabolic ratio of S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and metabolites was calculated. It is considered that the method for the quantitative analysis of S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and its metabolites in human plasma samples may contribute to the literature on account of its sensitive and easy application. Additionally, the use of our data by physicians will contribute to the effective drug treatment for their patients who take S\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bcpt.13133","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T13:23:46Z","timestamp":1537104226000},"page":"285-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitation of escitalopram and its metabolites by liquid chromatography\u2010tandem mass spectrometry in psychiatric patients: New metabolic ratio establishment"],"prefix":"10.1111","volume":"124","author":[{"given":"Fadime","family":"Canbolat","sequence":"first","affiliation":[{"name":"Clinical Pharmacogenetic Laboratory NP Brain Hospital \u00dcsk\u00fcdar University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek Meltem","family":"Tasdemir 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