{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:53:42Z","timestamp":1761562422844},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fonds de la Recherche du Qu\u00e9bec en Sant\u00e9"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of extracorporeal treatments (<jats:styled-content style=\"fixed-case\">ECTR<\/jats:styled-content>s) for poisonings with four non\u2010traditionally dialysed toxins (<jats:styled-content style=\"fixed-case\">NTDT<\/jats:styled-content>s) is increasing in the United States. This study evaluated whether <jats:styled-content style=\"fixed-case\">ECTR<\/jats:styled-content>s are prescribed for toxin removal or the treatment of other medical illnesses or complications. We performed a 2\u2010Phase retrospective analysis evaluating the main indication for <jats:styled-content style=\"fixed-case\">ECTR<\/jats:styled-content>s in patients with poisoning from a <jats:styled-content style=\"fixed-case\">NTDT<\/jats:styled-content> (defined for this study as acetaminophen, opioids, tricyclic antidepressants (<jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content>s) or digoxin) and <jats:styled-content style=\"fixed-case\">ECTR<\/jats:styled-content>. The first phase assessed all cases from a single site (New York City Poison Control Center) between the years 2000 and 2016, and the second phase surveyed all United States Poison Control Centers (<jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>s). In Phase 1, demographics, toxin ingested and main indication for <jats:styled-content style=\"fixed-case\">ECTR<\/jats:styled-content> were extracted. In Phase 2, a query to the National Poison Data System using the a pragmatic subset of inclusion criteria from Phase 1 restricted to single toxin ingestions over a narrower time frame (2014\u20102016) provided the cases for study. A structured online questionnaire was sent to all United States <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>s to request their database review regarding the indication for <jats:styled-content style=\"fixed-case\">ECTR<\/jats:styled-content> for their cases. In Phase 1, 92 cases met inclusion criteria. In Phase 2, 519 cases were screened and 425 met inclusion criteria. In Phase 1 91\/92 (98.9%) and Phase 2 411\/425 (96.7%), of extracorporeal treatments were used to treat underlying medical conditions or poisoning\u2010related complications rather than accelerate toxin removal. The increasing number of <jats:styled-content style=\"fixed-case\">ECTR<\/jats:styled-content>s reported in patients who ingested one of the four <jats:styled-content style=\"fixed-case\">NTDT<\/jats:styled-content>s thus appears to be for medical indications rather than attempts at toxin removal, a distinction that is important.<\/jats:p>","DOI":"10.1111\/bcpt.13135","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T17:03:12Z","timestamp":1537808592000},"page":"341-347","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extracorporeal treatments in poisonings from four non\u2010traditionally dialysed toxins (acetaminophen, digoxin, opioids and tricyclic antidepressants): A combined single\u2010centre and national study"],"prefix":"10.1111","volume":"124","author":[{"given":"Gabriel H.","family":"Campion","sequence":"first","affiliation":[{"name":"NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh J.","family":"Wang","sequence":"additional","affiliation":[{"name":"McGill University Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"NYU School of Medicine New York New York"},{"name":"New York City Poison Control Center New York New York"},{"name":"Montreal Medical Toxicology Initiative Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Cormier","sequence":"additional","affiliation":[{"name":"Montreal Medical Toxicology Initiative Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ry","family":"Lavergne","sequence":"additional","affiliation":[{"name":"University of Montreal Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Mowry","sequence":"additional","affiliation":[{"name":"Indiana Poison Center Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren M.","family":"Roberts","sequence":"additional","affiliation":[{"name":"New South Wales Poisons Information Centre Sydney Children's Hospital Network Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"University of Montreal Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark K.","family":"Su","sequence":"additional","affiliation":[{"name":"NYU School of Medicine New York New York"},{"name":"New York City Poison Control Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Gosselin","sequence":"additional","affiliation":[{"name":"McGill University Montr\u00e9al Quebec Canada"},{"name":"Montreal Medical Toxicology Initiative Montr\u00e9al Quebec Canada"},{"name":"McGill University Health Center Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.462"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12448"},{"key":"e_1_2_8_4_1","first-page":"257","article-title":"About drug dialyzability","volume":"42","author":"Sefer S","year":"2003","journal-title":"Acta Clin Croat"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.03.031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1035441"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10021014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000708"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.946994"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1118488"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12227"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12520"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001885"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12251"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.13135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.13135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:38:53Z","timestamp":1694212733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.13135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,31]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/bcpt.13135"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.13135","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,31]]},"assertion":[{"value":"2018-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}