{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:46:23Z","timestamp":1771879583035,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010term use of benzodiazepines or benzodiazepine receptor agonists is widespread, although guidelines recommend short\u2010term use. Only few controlled studies have characterized the effect of discontinuation of their chronic use on sleep and quality of life. We studied perceived sleep and quality of life in 92 older (age 55\u201091\u00a0years) outpatients with primary insomnia before and after withdrawal from long\u2010term use of zopiclone, zolpidem or temazepam (<jats:styled-content style=\"fixed-case\">BZDA<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">BZDA<\/jats:styled-content> was withdrawn during 1\u00a0month, during which the participants received psychosocial support and blindly melatonin or placebo. A questionnaire was used to study perceived sleep and quality of life before withdrawal, and 1\u00a0month and 6\u00a0months later. 89 participants completed the 6\u2010month follow\u2010up. As melatonin did not improve withdrawal, all participants were pooled and then separated based solely on the withdrawal results at 6\u00a0months (34 Withdrawers. 55 Nonwithdrawers) for this secondary analysis. At 6\u00a0months, the Withdrawers had significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) shorter sleep\u2010onset latency and less difficulty in initiating sleep than at baseline and when compared to Nonwithdrawers. Compared to baseline, both Withdrawers and Nonwithdrawers had at 6\u00a0months significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) less fatigue during the morning and daytime. Stress was alleviated more in Withdrawers than in Nonwithdrawers (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Satisfaction with life and expected health 1\u00a0year later improved (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in Withdrawers. In conclusion, sleep disturbances, daytime fatigue and impaired quality of life may resolve within 6\u00a0months of <jats:styled-content style=\"fixed-case\">BZDA<\/jats:styled-content> withdrawal. These results encourage withdrawal from chronic use of benzodiazepine\u2010type hypnotics, particularly in older subjects.<\/jats:p>","DOI":"10.1111\/bcpt.13144","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T09:09:00Z","timestamp":1538989740000},"page":"330-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Withdrawal from long\u2010term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia"],"prefix":"10.1111","volume":"124","author":[{"given":"Ritva","family":"L\u00e4hteenm\u00e4ki","sequence":"first","affiliation":[{"name":"Department of Family Medicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pertti J.","family":"Neuvonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University of Helsinki, and HUSLAB Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Puustinen","sequence":"additional","affiliation":[{"name":"Unit of Neurology Satakunta Hospital District Pori Finland"},{"name":"Division of Pharmacology and Pharmacotherapy Clinical Pharmacy Group University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tero","family":"Vahlberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Partinen","sequence":"additional","affiliation":[{"name":"Helsinki Sleep Clinic Vitalmed Research Center Helsinki Finland"},{"name":"Department of Neurology University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismo","family":"R\u00e4ih\u00e4","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirkka\u2010Liisa","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Turku Turku Finland"},{"name":"Division of Pharmacology and Pharmacotherapy Clinical Pharmacy Group University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0198-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2009.00537.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03563.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12684"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522090-00004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.357"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-14-121"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6177(03)00096-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1613-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2011-200314"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-000850"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415616695"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38623.768588.47"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1424-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.189.3.213"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02364.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.925444"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.126003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2257-8"},{"key":"e_1_2_7_21_1","unstructured":"Finnish Statistics on Medicines2009.Finnish Medicines Agency Fimea and Social Insurance Institution Helsinki;2010."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.27.2.239"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291703008213"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12294"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199910)14:10<858::AID-GPS35>3.0.CO;2-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1995.tb00205.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(90)90009-W"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0274"},{"key":"e_1_2_7_29_1","unstructured":"Medicine AAoS International Classification of Sleep Disorders.American Academy of Sleep Medicine 2014; Third Edition (ICSD\u20103)"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04418.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00212782"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.13144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.13144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:38:43Z","timestamp":1694212723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.13144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/bcpt.13144"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.13144","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"assertion":[{"value":"2018-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}