{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:53:20Z","timestamp":1789502000763,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T00:00:00Z","timestamp":1545696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This meta\u2010analysis was conducted to derive an integrated conclusion about the influence of glutathione S\u2010transferase (GST) genetic polymorphisms on busulfan pharmacokinetic (PK) parameters and veno\u2010occlusive disease (VOD). Studies which analysed the effect of\n                    <jats:italic>GST<\/jats:italic>\n                    genetic polymorphisms on area under the curve (AUC), clearance (CL) or VOD were searched for and selected. A pooled analysis was conducted using Comprehensive Meta\u2010Analysis programme. Nineteen studies were included in this meta\u2010analysis.\n                    <jats:italic>GSTA1<\/jats:italic>\n                    *B and\n                    <jats:italic>GSTM1<\/jats:italic>\n                    null genotypes significantly decreased CL\n                    <jats:sub>IV<\/jats:sub>\n                    of busulfan (standardized difference in means (SDM)\u00a0=\u00a0\u22121.103;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.019 and SDM\u00a0=\u00a0\u22120.418;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.002, respectively).\n                    <jats:italic>GSTA1<\/jats:italic>\n                    *B significantly increased AUC\n                    <jats:sub>IV<\/jats:sub>\n                    of busulfan (SDM\u00a0=\u00a00.832;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.046), whereas\n                    <jats:italic>GSTM1<\/jats:italic>\n                    did not (SDM\u00a0=\u00a00.155;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.478). The PK parameters of oral busulfan did not differ according to\n                    <jats:italic>GST<\/jats:italic>\n                    genotype.\n                    <jats:italic>GSTA1, GSTM1<\/jats:italic>\n                    and\n                    <jats:italic>GSTP1<\/jats:italic>\n                    were not significantly associated with VOD occurrence.\n                    <jats:italic>GSTA1<\/jats:italic>\n                    and\n                    <jats:italic>GSTM1<\/jats:italic>\n                    genotypes affected CL\n                    <jats:sub>IV<\/jats:sub>\n                    of busulfan, but only\n                    <jats:italic>GSTA1<\/jats:italic>\n                    affected AUC\n                    <jats:sub>IV<\/jats:sub>\n                    . There was no significant difference in the PK parameters of oral busulfan (CL\n                    <jats:sub>PO<\/jats:sub>\n                    and AUC\n                    <jats:sub>PO<\/jats:sub>\n                    ) and VOD when only\n                    <jats:italic>GST<\/jats:italic>\n                    genotypes were considered.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.13185","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T23:18:33Z","timestamp":1543879113000},"page":"691-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of glutathione S\u2010transferase genetic polymorphisms on busulfan pharmacokinetics and veno\u2010occlusive disease in hematopoietic stem cell transplantation: A meta\u2010analysis"],"prefix":"10.1111","volume":"124","author":[{"given":"Myeong Gyu","family":"Kim","sequence":"first","affiliation":[{"name":"Graduate School of Clinical Pharmacy CHA University Pocheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arim","family":"Kwak","sequence":"additional","affiliation":[{"name":"College of Pharmacy Korea University Sejong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyoon","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhee","family":"Ji","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences College of Pharmacy Gachon University Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Mi","family":"Oh","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungim","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Korea University Sejong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,25]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","first-page":"225","article-title":"Association of busulfan area under the curve with veno\u2010occlusive disease following BMT","volume":"17","author":"Dix SP","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703612"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"31","article-title":"Graft\u2010rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics","volume":"16","author":"Slattery JT","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702371"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2002.v8.pm12374452"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01529.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.8.3055"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.12.489"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","unstructured":"CzerwinskiM GibbsJ SlatteryTJ.Busulfan conjugation by Glutathione S\u2010Transferases alpha mu and pi1996.1015\u20101019.","DOI":"10.1016\/S0090-9556(25)07498-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200215666140202214012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200111000-00004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.124518"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.9.1685"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.297"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001666"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201500236"},{"key":"e_1_2_6_20_1","unstructured":"HigginsJ GreenS.Cochrane Handbook for Systematic Reviews of Interventions. 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