{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:41:22Z","timestamp":1721918482839},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T00:00:00Z","timestamp":1549152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A cross\u2010national comparison was performed on paediatric (0\u201019\u00a0years) antibiotic use in Hungary, Norway and Portugal to explore and compare the scale and pattern of paediatric antibiotic use in these three European countries. Ambulatory care systemic antibiotic use (ATC: J01) was retrieved from national databases for year 2014. The main outcome measure was number of antibacterial packages per child inhabitant per year (packages\/child\/year) and was further stratified by age groups. Paediatric antibiotic use peaked in Hungary with 1.3 packages\/child\/year, followed by Portugal (0.8) and Norway (0.3). This ranking was retained and was most prominent in the 5\u2010 to 9\u2010year and 10\u2010 to 14\u2010year age groups. The pattern of antibiotic use in different paediatric age groups varied also substantially between countries. Narrow\u2010spectrum penicillins were much commonly used in Norway in all paediatric age subgroups in comparison with Hungary and Portugal. Newer, broad\u2010spectrum cephalosporins and macrolides were widely prescribed for Hungarian and Portuguese children in all paediatric subgroups in contrast to Norway, while tetracyclines were commonly prescribed for Norwegian adolescents. The scale and pattern of paediatric antibiotic use in Hungary and Portugal were very different compared with Norway. The high antibiotic exposure and the high consumption of broad\u2010spectrum penicillins begin in childhood in Hungary and Portugal which underpins the responsibility of paediatric GPs.<\/jats:p>","DOI":"10.1111\/bcpt.13198","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T21:13:36Z","timestamp":1545945216000},"page":"722-729","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cross\u2010national comparison of paediatric antibiotic use in Norway, Portugal and Hungary"],"prefix":"10.1111","volume":"124","author":[{"given":"Ria","family":"Benko","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy University of Szeged Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Matuz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Szeged Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Silva","sequence":"additional","affiliation":[{"name":"Information and Strategic Planning Directorate Infarmed IP \u2010 National Authority of Medicines and Health Products, Public Institut Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Information and Strategic Planning Directorate Infarmed IP \u2010 National Authority of Medicines and Health Products, Public Institut Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C\u00e9u","family":"Machado","sequence":"additional","affiliation":[{"name":"Executive Board Infarmed IP \u2010 National Authority of Medicines and Health Products, IP Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Furtado","sequence":"additional","affiliation":[{"name":"Information and Strategic Planning Directorate Infarmed IP \u2010 National Authority of Medicines and Health Products, Public Institut Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Githa","family":"Fungie Galistiani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Szeged Szeged Hungary"},{"name":"Faculty of Pharmacy Universitas Muhammadiyah Purwokerto Purwokerto Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reka","family":"Bordas","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Szeged Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hege Salvesen","family":"Blix","sequence":"additional","affiliation":[{"name":"Department of Drug Statistics Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,3]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"w13654","article-title":"Infections in pediatrics: old and new diseases","volume":"142","author":"Posfay\u2010Barbe KM","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-107"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-2857"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13097"},{"key":"e_1_2_7_6_1","volume-title":"Global Action Plan on Antimicrobial Resistance","author":"World Health Organization","year":"2015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2017-000518"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70318-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2015.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.183541"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3831"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw030"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp18X694409"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310981"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm032"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2346"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.11.027"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2826-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4905-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn385"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt385"},{"key":"e_1_2_7_22_1","unstructured":"Eurostat.http:\/\/ec.europa.eu\/eurostat. 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