{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:58:00Z","timestamp":1771480680201,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community\u2010acquired pneumonia (CAP). The aim of this study was to investigate whether the effectiveness of a short\u2010course antibiotic is comparable to a longer course of antibiotics in adults with CAP and to assess whether the duration of an antibiotic course influences the development of resistant bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed in PubMed and EMBASE. We included randomized, controlled trials (RCTs) comparing clinical success, microbiological efficacy, patient safety and antibiotic resistance in a short\u2010course (5\u00a0days) vs a long\u2010course antibiotic treatment (7+\u00a0days) for CAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six RCTs were included. Clinical success rates were 87%\u201095% in patients treated with short\u2010course antibiotics and 88%\u201094% in patients treated with a longer course. Eradication of pathogenic bacteria was found to be 100% and 95%\u2010100% in patients treated with short\u2010course and long\u2010course antibiotics, respectively.<\/jats:p><jats:p>No significant differences in adverse events were reported. However, none of the trials reported on the impact on the development of resistant bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only few trials were included in this review and more RCTs are highly needed to be able to provide solid evidence for optimal treatment durations for patients diagnosed with CAP. Importantly, fluoroquinolones were often the drug of choice, and trials testing beta\u2010lactam antibiotics, which are the type of antibiotics most often used in many European countries, should be aimed for in near future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcpt.13205","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T22:17:42Z","timestamp":1548800262000},"page":"550-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Short\u2010course vs long\u2010course antibiotic treatment for community\u2010acquired pneumonia: A literature review"],"prefix":"10.1111","volume":"124","author":[{"given":"Kamilla","family":"M\u00f8ller Gundersen","sequence":"first","affiliation":[{"name":"Section of General Practice and Research Unit for General Practice, Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jette","family":"Nygaard Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Herlev and Gentofte Hospital University of Copenhagen Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Bjerrum","sequence":"additional","affiliation":[{"name":"Section of General Practice and Research Unit for General Practice, Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene Plejdrup","family":"Hansen","sequence":"additional","affiliation":[{"name":"Section of General Practice and Research Unit for General Practice, Department of Public Health University of Copenhagen Copenhagen Denmark"},{"name":"Center for General Practice at Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmx037"},{"key":"e_1_2_7_3_1","unstructured":"Dansk Laegemiddel Information A\/S. min.medicin \u2013 information til patienten 2017.Udvikling af resistente bakterier. [online]. [Localised 16.05.18] Available from: https:\/\/min.medicin.dk\/Indledningsafsnit\/Afsnit\/3051."},{"key":"e_1_2_7_4_1","unstructured":"AMR\u2010review 2016.Review on antimicrobial resistance \u2013 Tackling drug\u2010resistant infections globally [online]. [Localised 16.05.18] Available from:https:\/\/amr-review.org\/sites\/default\/files\/160525_Final%20paper_with%20cover.pdf."},{"key":"e_1_2_7_5_1","unstructured":"Statens Serum Institut 2016.Antibiotikaforbrug i Danmark [online]. [Localised 16.05.18] Available from:https:\/\/www.ssi.dk\/Smitteberedskab\/Om%20overvaagning\/Antibiotikaforbrug%20og%20resistens\/Antibiotikaforbrug%20i%20Danmark.aspx."},{"key":"e_1_2_7_6_1","unstructured":"Raadet for Anvendelse af Dyr Sygehusmedicin (RADS) 2016.Behandlingsvejledning for hensigtm\u00e6ssig anvendelse af antibiotika i almen praksis \u2013 Nedre luftvejsinfektioner: akut bronkitis pneumoni KOL\u2010exacerbation [online]. [Localised 16.05.18] Available from:http:\/\/www.rads.dk\/media\/3995\/beh-antibiotika-lrti-quick-guide-267963.pdf."},{"key":"e_1_2_7_7_1","unstructured":"RegionH\u2013 Hvidovre hospital 2016.Kan man halvere behandlingstiden med antibiotika? [online]. [Localised 16.05.18] Available from:https:\/\/www.hvidovrehospital.dk\/presse-og-nyt\/pressemeddelelser-og-nyheder\/nyheder-fra-hvidovre-hospital\/Sider\/Kan-man-halvere-behandlingstiden-med-antibiotika.aspx."},{"key":"e_1_2_7_8_1","unstructured":"Anz Journal of surgery.Jadad Score [online]. 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