{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:13:22Z","timestamp":1788246802244,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute coronary syndrome (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) is one of the leading causes of mortality worldwide and negatively impacts healthcare costs, productivity and quality of life. Polymorbidity and polypharmacy predispose <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> patients to medication discrepancies between cardiologist\u2010prescribed medication and drug use by the patient, drug\u2010related problems (<jats:styled-content style=\"fixed-case\">DRP<\/jats:styled-content>s) and inadequate drug adherence. This study aimed to evaluate the impact of clinical pharmacist\u2013provided services on the outcome of <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> patients. This was a prospective, randomized, controlled study on <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> patients participating in a cardiac rehabilitation programme. Forty <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> patients were randomly assigned to either control group, who received standard medical care, or intervention group, who received standard medical care plus clinical pharmacist\u2013provided services. Services included <jats:styled-content style=\"fixed-case\">DRP<\/jats:styled-content> management, clinical assessment and enforcing the patient education and adherence. For both groups, the following were assessed at baseline and after 3\u00a0months: <jats:styled-content style=\"fixed-case\">DRP<\/jats:styled-content>s, adherence (assessed by 8\u2010item Morisky Adherence Questionnaire), patient's knowledge (assessed by Coronary Artery Disease Questionnaire), 36\u2010Short Form Health Survey (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036), heart rate, systolic and diastolic blood pressure, low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>), total cholesterol (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>) and fasting blood glucose (<jats:styled-content style=\"fixed-case\">FBG<\/jats:styled-content>). After 3\u00a0months, there was a significant difference between the intervention and control groups in the per cent change of <jats:styled-content style=\"fixed-case\">DRP<\/jats:styled-content>s (median: \u2212100 vs 5.882, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), patient's adherence score (median: 39.13 vs \u221214.58, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), knowledge score (median: 30.28 vs \u22125.196, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 scores, heart rate (mean: \u221210.04 vs 6.791, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), diastolic blood pressure (mean: \u221217.87 vs 10.45, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), systolic blood pressure (mean: \u221216.22 vs 4.751, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> (median: \u221225.73 vs \u22120.2538, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0071), <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> (median: \u221214.62 vs 4.123, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005) and <jats:styled-content style=\"fixed-case\">FBG<\/jats:styled-content> (median: \u221211.42 vs 5.422, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0098). Clinical pharmacists can play an important role as part of a cardiac rehabilitation team through patient education and interventions to minimize <jats:styled-content style=\"fixed-case\">DRP<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/bcpt.13210","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T07:56:00Z","timestamp":1549785360000},"page":"44-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Management of pharmacotherapy\u2010related problems in acute coronary syndrome: Role of clinical pharmacist in cardiac rehabilitation unit"],"prefix":"10.1111","volume":"125","author":[{"given":"Eman Ahmed","family":"Casper","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamiaa Mohamed","family":"El Wakeel","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ayman","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Cardiac Rehabilitation Unit Ain Shams University Hospitals Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Hamed","family":"El\u2010Hamamsy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy King Abdulaziz University Jeddah Saudi Arabia Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22241"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0456-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aphw.12062"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311890"},{"issue":"5","key":"e_1_2_9_6_1","first-page":"408","article-title":"A systematic review of the clinical and economic effectiveness of clinical pharmacist intervention in secondary prevention of cardiovascular disease","volume":"19","author":"Altowaijri A","year":"2013","journal-title":"J Manag Care Pharm"},{"key":"e_1_2_9_7_1","unstructured":"AdamsP BennetI CarverK et\u00a0al.Myocardial infarction: cardiac rehabilitation and prevention of further cardiovascular disease. 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