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Air pollutants prompt and promote chronic inflammation, tumourigenesis, autoimmune and other destructive processes in the human body. Post\u2010translational modification of proteins, for example citrullination, results from damaging attacks of pollutants, including smoking, air pollution and others, rendering host tissues immunogenic. Citrullinated proteins and citrullinating enzymes, deiminases, are more prevalent in patients with COPD and correlate with ongoing inflammation and oxidative stress. In this study, we installed an in\u2010house\u2013designed diesel exhaust delivery and cannabidiol vaporization system where mice were exposed to relevant, urban traffic\u2013related levels of diesel exhaust for 14\u00a0days and assessed integrity of alveolar tissue, gene expression shifts and changes in protein content in the lungs and other tissues of exposed mice. Systemic presence of modified proteins was also tested. The protective effect of phytocannabinoids was investigated as well. Data obtained in our study show subacute effects of diesel exhaust on mouse lung integrity and protein content. Emphysematous changes are documented in exposed mouse lungs. In parallel, increased levels of citrulline were detected in the alveolar lung tissue and peripheral blood of exposed mice. Pre\u2010treatment with vaporized cannabidiol ameliorated some damaging effects. Results reported hereby provide new insights into subacute lung tissue changes that follow diesel exhaust exposure and suggest possible dietary and\/or other therapeutic interventions for maintaining lung health and healthy ageing.<\/jats:p>","DOI":"10.1111\/bcpt.13213","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T05:27:48Z","timestamp":1551158868000},"page":"166-177","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lung alveolar tissue destruction and protein citrullination in diesel exhaust\u2010exposed mouse lungs"],"prefix":"10.1111","volume":"125","author":[{"given":"Ieva","family":"Kulvinskiene","sequence":"first","affiliation":[{"name":"State Research Institute Center for Innovative Medicine Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovile","family":"Raudoniute","sequence":"additional","affiliation":[{"name":"State Research 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