{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:41:40Z","timestamp":1775594500034,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["14172MFDS159"],"award-info":[{"award-number":["14172MFDS159"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Considering the concerns about topical corticosteroid (TC) phobia that prevents necessary use of patients from using the necessary TCs, estimating the incidence and characteristics of adverse drug events (ADEs) related to TCs in the real world is warranted. However, limited study investigated them. This prospective observational study aimed to assess the utility patterns and safety data related to TC use and predisposing factors among community\u2010dwelling population. We included and prospectively observed the TC users through nationwide multi\u2010centre observational cohort based on community pharmacies and dermatologic clinic. Among the enrolled 1175 over\u2010the\u2010counter and prescription TC users, a total of 1103 participants were included for the analysis. Inappropriate TC use was observed in 6.3%. The cumulative incidence and prevalence of overall ADE for 6\u00a0months were 3.5% and 7.2%, respectively, and the incidence rate was 0.3 cases per 1000 person\u2010days of TC use. Most ADEs were local reactions, mainly skin atrophy and hyperpigmentation. Exposure to TCs for &gt;12\u00a0weeks (adjusted odds ratio [aOR] 4.38, 95% confidence interval [CI] 2.23\u20108.63) and past experience of ADE (aOR 36.70, 95% CI 16.74\u201080.44) were identified as significant predictors of TC\u2010related ADEs. The ADE incidence related to TCs was relatively low, and the real\u2010world safety of using TCs in the general population might not be greatly concerning. However, some populations who are highly at a risk of ADEs should be closely monitored and made aware regarding the risk.<\/jats:p>","DOI":"10.1111\/bcpt.13238","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T06:40:31Z","timestamp":1555310431000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Real\u2010world safety evaluation of topical corticosteroid use: A community pharmacy\u2010based, prospective, observational study"],"prefix":"10.1111","volume":"125","author":[{"given":"Young\u2010Mi","family":"Ah","sequence":"first","affiliation":[{"name":"College of Pharmacy Yeungnam University Gyeongsangbuk\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunghee","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Pharmaceutical Science and Technology Hanyang University Ansan, Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwanghee","family":"Jun","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo An","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy Korea University Sejong\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Mi","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Yonsei University Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EunYoung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Gyoon","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Yeun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.055"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.023"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5645.670"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.04934.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70040-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(02)00365-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.11.1173"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.18021.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L067"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087288"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10449.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.18502\/sjms.v13i1.1689"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011080"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(94)90057-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2013.063"},{"issue":"2","key":"e_1_2_7_19_1","first-page":"135","article-title":"Choosing topical corticosteroids","volume":"79","author":"Ference JD","year":"2009","journal-title":"Am Fam Physician."},{"key":"e_1_2_7_20_1","unstructured":"National Institute for Health and Clinical Excellence: Guidance.Psoriasis: Assessment and Management of Psoriasis. October 2012. Available at:https:\/\/www.nice.org.uk\/guidance\/cg153. Accessed December 01 2014."},{"key":"e_1_2_7_21_1","unstructured":"National Institute for Health and Clinical Excellence: Guidance.Atopic eczema in under 12s: diagnosis and management. December 2007. Available at:https:\/\/www.nice.org.uk\/guidance\/cg57\/ifp\/chapter\/About-this-information. 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